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Title: 5[prime] to 3[prime] nucleic acid synthesis using 3[prime]-photoremovable protecting group

The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5[prime] to 3[prime] nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5[prime] end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.
Authors:
; ;
Publication Date:
OSTI Identifier:
6478659
Report Number(s):
US 5908926; A
PPN: US 8-406327
DOE Contract Number:
FG05-92ER61388
Resource Type:
Patent
Resource Relation:
Patent File Date: 16 Mar 1995
Sponsoring Org:
DOE; USDOE, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHEMICAL ANALYSIS; CHEMICAL PREPARATION; MUTATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; SYNTHESIS 550200* -- Biochemistry