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Title: Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin

Abstract

The authors have developed a new method to quantitate changes in coronary blood flow (CBF) by single photon emission tomography (SPECT) of dual-labelled intracoronary human albumin microspheres (HAM) before and after an intervention. After initial validation in pigs, the authors studied 20 pts in the cath lab with 10 pts receiving saline to serve as controls, and 10 pts receiving nitroglycerin (NTG). Thermodilution coronary sinus flow (CSF) measurements were made at rest and after each intervention. After pacing to mild angina, serial injections of Tc-99m HAM, 40 ..mu..g of NTG or saline, and In-111 HAM were made in the left main coronary artery. After routine coronary arteriography, the pt underwent dual-peak SPECT with the image slices reconstructed along the longitudinal axis of the heart. Quantitative circumferential profiles were made for each slice by plotting the average count per pixel in each 18/sup 0/ segment of the left ventricle. After correction for absolute coronary blood flow, the difference between the pre- and post-NTG profile was obtained, and a significant change took place if it exceeded 2 S.D. from control. The segments were classified into normal, mildly, moderately or severely comprised territories according to upstream coronary anatomy. Results are presented. The authorsmore » conclude: (1) SPECT of intracoronary HAM combined with CSF measurement represents a powerful tool in assessing changes in regional CBF after an intervention; (2) By this method, NTG gave preferential redistribution of CBF to the mild and moderately ischemic zones of the heart.« less

Authors:
; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
6476585
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-022237
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; BLOOD FLOW; DYNAMIC FUNCTION STUDIES; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IMAGE PROCESSING; ANATOMY; CARDIOVASCULAR AGENTS; CORONARIES; ISCHEMIA; NITROGLYCERIN; RADIOCARDIOGRAPHY; RADIOISOTOPE SCANNING; RADIOPHARMACEUTICALS; UPTAKE; ARTERIES; BLOOD VESSELS; BODY; CARDIOGRAPHY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CHEMICAL EXPLOSIVES; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; ESTERS; EXPLOSIVES; LABELLED COMPOUNDS; NITRIC ACID ESTERS; ORGANIC COMPOUNDS; ORGANS; PROCESSING; TOMOGRAPHY; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Liu, P, Houle, S, Kimball, B, Burns, R J, Gilday, D, Weisel, R D, Warbick-Cerone, A, Johnston, L, and McLaughlin, P R. Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin. United States: N. p., 1984. Web.
Liu, P, Houle, S, Kimball, B, Burns, R J, Gilday, D, Weisel, R D, Warbick-Cerone, A, Johnston, L, & McLaughlin, P R. Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin. United States.
Liu, P, Houle, S, Kimball, B, Burns, R J, Gilday, D, Weisel, R D, Warbick-Cerone, A, Johnston, L, and McLaughlin, P R. 1984. "Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin". United States.
@article{osti_6476585,
title = {Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin},
author = {Liu, P and Houle, S and Kimball, B and Burns, R J and Gilday, D and Weisel, R D and Warbick-Cerone, A and Johnston, L and McLaughlin, P R},
abstractNote = {The authors have developed a new method to quantitate changes in coronary blood flow (CBF) by single photon emission tomography (SPECT) of dual-labelled intracoronary human albumin microspheres (HAM) before and after an intervention. After initial validation in pigs, the authors studied 20 pts in the cath lab with 10 pts receiving saline to serve as controls, and 10 pts receiving nitroglycerin (NTG). Thermodilution coronary sinus flow (CSF) measurements were made at rest and after each intervention. After pacing to mild angina, serial injections of Tc-99m HAM, 40 ..mu..g of NTG or saline, and In-111 HAM were made in the left main coronary artery. After routine coronary arteriography, the pt underwent dual-peak SPECT with the image slices reconstructed along the longitudinal axis of the heart. Quantitative circumferential profiles were made for each slice by plotting the average count per pixel in each 18/sup 0/ segment of the left ventricle. After correction for absolute coronary blood flow, the difference between the pre- and post-NTG profile was obtained, and a significant change took place if it exceeded 2 S.D. from control. The segments were classified into normal, mildly, moderately or severely comprised territories according to upstream coronary anatomy. Results are presented. The authors conclude: (1) SPECT of intracoronary HAM combined with CSF measurement represents a powerful tool in assessing changes in regional CBF after an intervention; (2) By this method, NTG gave preferential redistribution of CBF to the mild and moderately ischemic zones of the heart.},
doi = {},
url = {https://www.osti.gov/biblio/6476585}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

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