Assessment of gastric emptying in normal subjects with sucralfate (Carafate) and Amphojel
Aluminum-containing antacids (e.g Amphojel) and aluminum-containing compounds such as sucralfate (Carafate) have been shown in animal and human studies to delay gastric emptying, and are one proposed mechanism of action for healing of duodenal ulcers. Therefore, the authors designed a study to study the effects of Carafate and Amphojel on gastric emptying. Ten normal volunteers of mean age 27 years with no previous history of upper gastrointestinal diseases were studied. For each test the subject ingested a meal composed of 30gm of cooked chicken liver injected with lmCi of 99m-Tc-S-C, mixed with 7.5 oz. of beef stew, and eaten with 4 oz. of water labeled with 100..mu..Ci of 111-In-DTPA. Immediately after ingestion of the meal, the subject was placed supine under a gamma camera. Gastric emptying (GE) was expressed as percent emptied. On separate days the subject was given either lgm of Carafate (190mg Al/gm) or placebo in a double blind fashion one hour prior to the test meal. On the third day, each subject was given 30cc of Amphojel (105mg Al/5cc) followed 30 minutes later by the test meal. GE at 2 hours for the solid meal was 60%, 69%, and 54% and 79%, 86% and 68% at 3 hours for placebo, Carafate, and Amphojel respectively. A small but not significant difference in gastric emptying between Amphojel and placebo was seen from 2 to 3 hours. For the liquid meal approximately 90% emptying was present at 1 hour for all three studies. Further studies are needed to determine whether these medications administered in the standard doses given here may affect gastric emptying in duodenal ulcer patients.
- Research Organization:
- Hospital of St. Raphael, New Haven, CT
- OSTI ID:
- 6476226
- Report Number(s):
- CONF-840619-; TRN: 87-022252
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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DIGESTION
GASTROINTESTINAL TRACT
SCINTISCANNING
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
UPTAKE
STOMACH
ALUMINIUM COMPOUNDS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
DIET
DOSIMETRY
DYNAMIC FUNCTION STUDIES
FOOD
GAMMA CAMERAS
HEALING
LABELLING
RADIONUCLIDE KINETICS
ULCERS
BIOLOGICAL RECOVERY
BODY
CAMERAS
CHEMISTRY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
LABELLED COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RECOVERY
550601* - Medicine- Unsealed Radionuclides in Diagnostics