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Title: Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma

Abstract

In regional hyperthermic perfusion with melphalan for patients with malignant melanoma of the leg, plasma leakage between the perfusion circuit and the systemic circulation was 4-7 ml X min-1. The melphalan concentration in the perfusate was biphasic, with half-lives of 8-12 mins for the initial phase and 19-28 mins for the second phase, after the first dose. After a second dose, the corresponding values were 11-13 and 26-34 mins. The highest concentration in general circulation was 0.38 micrograms X ml-1.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of Gothenburg, Sweden
OSTI Identifier:
6472307
Resource Type:
Journal Article
Journal Name:
Cancer Treat. Rep.; (United States)
Additional Journal Information:
Journal Volume: 68:6
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHEMOTHERAPY; EVALUATION; HYPERTHERMIA; MELANOMAS; ALKYLATING AGENTS; HEMORRHAGE; IODINE ISOTOPES; LEGS; PATIENTS; PERFUSED TISSUES; RADIOTHERAPY; ANIMAL TISSUES; BODY; BODY AREAS; BODY TEMPERATURE; DISEASES; ISOTOPES; LIMBS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; PATHOLOGICAL CHANGES; RADIOLOGY; SYMPTOMS; THERAPY; TISSUES; 550600* - Medicine; 560206 - Thermal Effects- Man- (-1987)

Citation Formats

Hafstroem, L, Hugander, A, Joensson, P E, Westling, H, and Ehrsson, H. Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma. United States: N. p., 1984. Web.
Hafstroem, L, Hugander, A, Joensson, P E, Westling, H, & Ehrsson, H. Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma. United States.
Hafstroem, L, Hugander, A, Joensson, P E, Westling, H, and Ehrsson, H. 1984. "Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma". United States.
@article{osti_6472307,
title = {Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma},
author = {Hafstroem, L and Hugander, A and Joensson, P E and Westling, H and Ehrsson, H},
abstractNote = {In regional hyperthermic perfusion with melphalan for patients with malignant melanoma of the leg, plasma leakage between the perfusion circuit and the systemic circulation was 4-7 ml X min-1. The melphalan concentration in the perfusate was biphasic, with half-lives of 8-12 mins for the initial phase and 19-28 mins for the second phase, after the first dose. After a second dose, the corresponding values were 11-13 and 26-34 mins. The highest concentration in general circulation was 0.38 micrograms X ml-1.},
doi = {},
url = {https://www.osti.gov/biblio/6472307}, journal = {Cancer Treat. Rep.; (United States)},
number = ,
volume = 68:6,
place = {United States},
year = {Fri Jun 01 00:00:00 EDT 1984},
month = {Fri Jun 01 00:00:00 EDT 1984}
}