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Title: DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits

A recombinant DNA molecule is described comprising at least a portion coding for subunits A and B of cholera toxin, or a fragment or derivative of the portion wherein the fragment or derivative codes for a polypeptide have an activity which can induce an immune response to subunit A; can induce an immune response to subunit A and cause epithelial cell penetration and the enzymatic effect leading to net loss of fluid into the gut lumen; can bind to the membrane receptor for the B subunit of cholera toxin; can induce an immune response to subunit B; can induce an immune response to subunit B and bind to the membrane receptor; or has a combination of the activities.
Authors:
;
Publication Date:
OSTI Identifier:
6470592
Report Number(s):
US 4666837
Resource Type:
Patent
Resource Relation:
Patent File Date: Filed date 24 May 1982
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHOLERA; DNA SEQUENCING; RECOMBINANT DNA; ENDOTOXINS; ENZYME ACTIVITY; EPITHELIUM; IMMUNE REACTIONS; MEMBRANES; POLYPEPTIDES; RECEPTORS; TOXINS; ANIMAL TISSUES; ANTIGENS; BACTERIAL DISEASES; BODY; DISEASES; DNA; INFECTIOUS DISEASES; MATERIALS; MEMBRANE PROTEINS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PEPTIDES; PROTEINS; STRUCTURAL CHEMICAL ANALYSIS; TISSUES; TOXIC MATERIALS 550200* -- Biochemistry