Addition of cysteamine to thymine and thymidine monophosphate, initiated by. gamma. -irradiation

Journal Article · Sun Apr 20 00:00:00 EST 1986 · Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.); (United States)

OSTI ID:6470245

Grachev, S A; Kropachev, E V; Litvyakova, G I

On radiolysis of deaerated solutions containing thymine and cysteamine, or thymidine monophosphate and cysteamine, coupling products of these compounds are formed resulting from the addition of cysteamine to the double bond of the base. The radiochemical yields of the coupling products are dependent on the ratio of the concentration thymine (T) to that of cysteamine (RSH), or of thymidine monophosphate (TMP) to cysteamine in the irradiated solutions, and are at a maximum when (T)/(RSH) = 5-10, and (TMP)/(RSH) = 15-20. The mode of formation of coupling products involves reaction of H-, OH-, and e/sub aq//sup -/-adducts of thymine or thymidine monophosphate with cysteamine thiyl radicals.

• Research Organization: B.P. Konstantinov Leningrad Institute of Nuclear Physics, USSR
• OSTI ID: 6470245
• Journal Information: Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.); (United States), Vol. 34:10; Other Information: Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya; 34: No.10, 2351-2358(Oct 1985)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
MEA
BIOCHEMISTRY
CHEMICAL RADIATION EFFECTS
SODIUM PHOSPHATES
THYMIDYLIC ACID
THYMINE
BINDING ENERGY
CARBON 14 COMPOUNDS
CHEMICAL REACTION KINETICS
GAMMA RADIATION
ISOTOPE DILUTION
SULFUR 35
SYNTHESIS
TRITIUM COMPOUNDS
ALKALI METAL COMPOUNDS
AMINES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
ENERGY
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
PYRIMIDINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
SODIUM COMPOUNDS
SULFUR ISOTOPES
THIOLS
TRACER TECHNIQUES
URACILS
550201* - Biochemistry- Tracer Techniques
400600 - Radiation Chemistry