Analysis of the structure of synthetic and natural melanins by solid-phase
Abstract
The structures of one synthetic and two natural melanins are examined by solid-state NMR using cross polarization, magic angle sample spinning, and high-power proton decoupling. The structural features of synthetic dopa malanin are compared to those of melanin from malignant melanoma cells grown in culture and sepia melanin from squid ink. Natural abundance /sup 13/C and /sup 15/N spectra show resonances consistent with known pyrrolic and indolic structures within the heterogeneous biopolymer; /sup 13/C spectra indicate the presence of aliphatic residues in all three materials. These solid-phase experiments illustrate the promise of solid-phase NMR for elucidating structural from insoluble biomaterials.
- Authors:
- Publication Date:
- Research Org.:
- Lehigh Univ., Bethlehem, PA (USA)
- OSTI Identifier:
- 6469031
- Resource Type:
- Journal Article
- Journal Name:
- Biochemistry; (United States)
- Additional Journal Information:
- Journal Volume: 27:18
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; MELANIN; NUCLEAR MAGNETIC RESONANCE; CARBON 13; ELECTRON SPIN RESONANCE; MOLECULAR STRUCTURE; NITROGEN 15; PROTONS; BARYONS; CARBON ISOTOPES; ELEMENTARY PARTICLES; EVEN-ODD NUCLEI; FERMIONS; HADRONS; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; NITROGEN ISOTOPES; NUCLEI; NUCLEONS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PIGMENTS; RESONANCE; STABLE ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Duff, G A, Roberts, J E, and Foster, N. Analysis of the structure of synthetic and natural melanins by solid-phase. United States: N. p., 1988.
Web. doi:10.1021/bi00418a067.
Duff, G A, Roberts, J E, & Foster, N. Analysis of the structure of synthetic and natural melanins by solid-phase. United States. https://doi.org/10.1021/bi00418a067
Duff, G A, Roberts, J E, and Foster, N. 1988.
"Analysis of the structure of synthetic and natural melanins by solid-phase". United States. https://doi.org/10.1021/bi00418a067.
@article{osti_6469031,
title = {Analysis of the structure of synthetic and natural melanins by solid-phase},
author = {Duff, G A and Roberts, J E and Foster, N},
abstractNote = {The structures of one synthetic and two natural melanins are examined by solid-state NMR using cross polarization, magic angle sample spinning, and high-power proton decoupling. The structural features of synthetic dopa malanin are compared to those of melanin from malignant melanoma cells grown in culture and sepia melanin from squid ink. Natural abundance /sup 13/C and /sup 15/N spectra show resonances consistent with known pyrrolic and indolic structures within the heterogeneous biopolymer; /sup 13/C spectra indicate the presence of aliphatic residues in all three materials. These solid-phase experiments illustrate the promise of solid-phase NMR for elucidating structural from insoluble biomaterials.},
doi = {10.1021/bi00418a067},
url = {https://www.osti.gov/biblio/6469031},
journal = {Biochemistry; (United States)},
number = ,
volume = 27:18,
place = {United States},
year = {Tue Sep 06 00:00:00 EDT 1988},
month = {Tue Sep 06 00:00:00 EDT 1988}
}
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