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Title: Effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants

The effects of hematocrit and systolic blood pressure on cerebral blood flow were measured in 15 stable, low birth weight babies. CBF was measured with a modification of the xenon-133 (/sup 133/Xe) clearance technique, which uses an intravenous bolus of /sup 133/Xe, an external chest detector to estimate arterial /sup 133/Xe concentration, eight external cranial detectors to measure cephalic /sup 133/Xe clearance curves, and a two-compartmental analysis of the cephalic /sup 133/Xe clearance curves to estimate CBF. There was a significant inverse correlation between hematocrit and CBF, presumably due to alterations in arterial oxygen content and blood viscosity. Newborn CBF varied independently of systolic blood pressure between 60 and 84 mm Hg, suggesting an intact cerebrovascular autoregulatory mechanism. These results indicate that at least two of the factors that affect newborn animal CBF are operational in human newborns and may have important clinical implications.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
6468181
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Cereb. Blood Flow Metab.; (United States); Journal Volume: 3
Research Org:
Univ. of Pennsylvania, Philadelphia
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; BLOOD FLOW; BLOOD COUNT; BLOOD PRESSURE; CLEARANCE; DYNAMIC FUNCTION STUDIES; HOMEOSTASIS; INFANTS; TRACER TECHNIQUES; XENON 133; AGE GROUPS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; CHILDREN; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; RADIOISOTOPES; XENON ISOTOPES 551001* -- Physiological Systems-- Tracer Techniques