Subacute radiation dermatitis: a histologic imitator of acute cutaneous graft-versus-host disease
The histopathologic changes of radiation dermatitis have been classified either as early effects (necrotic keratinocytes, fibrin thrombi, and hemorrhage) or as late effects (vacuolar changes at the dermal-epidermal junction, atypical radiation fibroblasts, and fibrosis). Two patients, one exposed to radiation therapeutically and one accidentally, are described. Skin biopsy specimens showed an interface dermatitis characterized by numerous dyskeratotic epidermal cells with lymphocytes in close apposition (satellite cell necrosis); that is, the epidermal changes were similar to those in acute graft-versus-host disease. Because recipients of bone marrow transplants frequently receive total body irradiation as part of their preparatory regimen, the ability of radiation to cause persistent epidermal changes similar to those in acute graft-versus-host disease could complicate the interpretation of posttransplant skin biopsy specimens.
- Research Organization:
- Univ. of California, San Francisco (USA)
- OSTI ID:
- 6466181
- Journal Information:
- J. Am. Acad. Dermatol.; (United States), Vol. 20
- Country of Publication:
- United States
- Language:
- English
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RADIOTHERAPY
SIDE EFFECTS
SKIN
BIOLOGICAL RADIATION EFFECTS
DATA COVARIANCES
GRAFT-HOST REACTION
LYMPHOCYTES
NECROSIS
PATIENTS
RADIATION INJURIES
RADIODERMATITIS
SKIN DISEASES
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DERMATITIS
DISEASES
INJURIES
LEUKOCYTES
LOCAL RADIATION EFFECTS
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
SOMATIC CELLS
THERAPY
560151* - Radiation Effects on Animals- Man