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Title: Synthesis of an indole analog of folic acid

Abstract

The authors study the replacement of the p-aminobenzoic acid (PABA) moiety. The authors synthesized an indole analog of folic acid, namely dimethyl N-(5-(2'-amino-4'-oxo-6'-pteridinyl)methylaminoindol-2-yl)glutamate. The physicochemical properties and the chemical shifts in the PMR spectra of the compounds obtained are shown. The examination of the compound for antitumor activity was carried out using rats and mice.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
D.I. Mendeleev Moscow Institute of Chemistry and Technology (USSR)
OSTI Identifier:
6465655
Resource Type:
Journal Article
Journal Name:
Pharmaceut. Chem. J.; (United States)
Additional Journal Information:
Journal Volume: 20:8; Other Information: Translated from Khimiko-Farmatsevticheski Zhurnal; 20: No. 8, 932-938(Aug 1986)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 74 ATOMIC AND MOLECULAR PHYSICS; ANTINEOPLASTIC DRUGS; MATERIALS TESTING; CARBOXYLIC ACID ESTERS; BIOLOGICAL EFFECTS; NMR SPECTRA; SYNTHESIS; INDOLES; CHEMICAL SHIFT; COUPLING CONSTANTS; FOLIC ACID; GLUTAMIC ACID; INFRARED SPECTRA; J-J COUPLING; LEUKEMIA; MICE; PHARMACOLOGY; STRUCTURAL CHEMICAL ANALYSIS; ULTRAVIOLET SPECTRA; AMINO ACIDS; ANIMALS; AROMATICS; AZAARENES; AZOLES; CARBOXYLIC ACIDS; COUPLING; DISEASES; DRUGS; ESTERS; HEMATINICS; HEMATOLOGIC AGENTS; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMMUNE SYSTEM DISEASES; INTERMEDIATE COUPLING; MAMMALS; NEOPLASMS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PTERIDINES; PYRROLES; RODENTS; SPECTRA; TESTING; VERTEBRATES; VITAMIN B GROUP; VITAMINS; 550200* - Biochemistry; 640302 - Atomic, Molecular & Chemical Physics- Atomic & Molecular Properties & Theory

Citation Formats

Shengeliya, M S, Avramenko, V G, Kuleshova, L N, Ershova, Yu A, Chernov, V A, and Surorov, N N. Synthesis of an indole analog of folic acid. United States: N. p., 1987. Web.
Shengeliya, M S, Avramenko, V G, Kuleshova, L N, Ershova, Yu A, Chernov, V A, & Surorov, N N. Synthesis of an indole analog of folic acid. United States.
Shengeliya, M S, Avramenko, V G, Kuleshova, L N, Ershova, Yu A, Chernov, V A, and Surorov, N N. 1987. "Synthesis of an indole analog of folic acid". United States.
@article{osti_6465655,
title = {Synthesis of an indole analog of folic acid},
author = {Shengeliya, M S and Avramenko, V G and Kuleshova, L N and Ershova, Yu A and Chernov, V A and Surorov, N N},
abstractNote = {The authors study the replacement of the p-aminobenzoic acid (PABA) moiety. The authors synthesized an indole analog of folic acid, namely dimethyl N-(5-(2'-amino-4'-oxo-6'-pteridinyl)methylaminoindol-2-yl)glutamate. The physicochemical properties and the chemical shifts in the PMR spectra of the compounds obtained are shown. The examination of the compound for antitumor activity was carried out using rats and mice.},
doi = {},
url = {https://www.osti.gov/biblio/6465655}, journal = {Pharmaceut. Chem. J.; (United States)},
number = ,
volume = 20:8,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 1987},
month = {Mon Jun 01 00:00:00 EDT 1987}
}