Cadmium concentration in the kidney cortex of occupationally exposed workers measured in vivo using X-ray fluorescence analysis

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80216-5· OSTI ID:6465021

Christoffersson, J O; Welinder, H; Spang, G M; Mattsson, S; Skerfving, S

A method for in vivo X-ray fluorescence analysis of the cadmium concentration in the kidney cortex has been improved and tested in 20 selected male occupationally cadmium-exposed workers (duration of exposure 7-39 years). The concentration of cadmium in kidney cortex ranged from 47 to 317 (median 141) micrograms/g. The concentration of cadmium in blood was 32-160 (median 64) nmole/liter, cadmium in urine was 2.5-13 (median 5.4) nmole/mmole creatinine, and beta 2-microglobulin in urine was 3.3-68 (median 14) micrograms/mmole creatinine. In individuals, the relationship between duration of exposure, time-integrated exposure, and cadmium level in urine on the one hand and cadmium level in the kidney on the other varied considerably. Direct in vivo analysis of the concentration of cadmium in the kidney cortex is therefore valuable as a complement to the other tests when monitoring cadmium exposure. Our method is sensitive, practically free from risk, and can b performed by routine at low costs.

• Research Organization: Lund Univ., Malmoe General Hospital, Sweden
• OSTI ID: 6465021
• Journal Information: Environ. Res.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CADMIUM
X-RAY FLUORESCENCE ANALYSIS
KIDNEYS
AIR POLLUTION
BLOOD CHEMISTRY
IN VIVO
MEN
MONITORING
OCCUPATIONAL EXPOSURE
TIME DEPENDENCE
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
ELEMENTS
MALES
MAMMALS
MAN
MATERIALS
METALS
NONDESTRUCTIVE ANALYSIS
ORGANS
POLLUTION
PRIMATES
VERTEBRATES
WASTES
X-RAY EMISSION ANALYSIS
560300* - Chemicals Metabolism & Toxicology
400101 - Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures