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Title: Correlates of diuretic renography in experimental hydronephrosis

We studied the correlations between diuretic renographs and kidney function in experimental hydronephrosis in rabbits. Features of furosemide-stimulated /sup 99m/Tc-diethylenetriamine-pentaacetic acid renographs were compared to the growth rate, thirst test and endogenous creatinine clearance rate in a chronic solitary-kidney animal model. Intravenous pyelograms, done four weeks after laparotomy, left nephrectomy, bladder resection and constriction of the right pyeloureteric junction, showed signs of obstruction in all the 12 animals of the experimental group. An absent tracer washout after intravenous furosemide, found in five animals, was associated with retarded growth, isosthenuria and an abnormal creatinine clearance. In all of the other seven animals, a distinct tracer washout after intravenous furosemide was accompanied with a normal growth rate and creatinine clearance. However, no one of these seven animals had a normal ability to retain water and concentrate urine in the thirst test. We conclude that, in this experimental model, a furosemide-induced tracer washout from the kidney pelvis cannot be taken as a proof of the absence of any upper urinary tract obstruction.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6463638
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Urol.; (United States); Journal Volume: 141:2
Research Org:
Turku Univ. Central Hospital (Finland)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CREATININE; RENAL CLEARANCE; KIDNEYS; BIOMEDICAL RADIOGRAPHY; UROGENITAL SYSTEM DISEASES; DIAGNOSIS; BIOLOGICAL MODELS; DTPA; DYNAMIC FUNCTION STUDIES; ISOMERIC NUCLEI; NEPHRECTOMY; ORGANOMETALLIC COMPOUNDS; RABBITS; TECHNETIUM 99; TRACER TECHNIQUES; AMINO ACIDS; ANIMALS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEARANCE; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EXCRETION; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; IMIDAZOLES; IMINES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPES; RADIOLOGY; RADIOPROTECTIVE SUBSTANCES; SURGERY; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics