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Title: Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives

Abstract

Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).

Authors:
; ; ; ;
Publication Date:
Research Org.:
Universite des Sciences et Techniques du Languedoc, Montpellier (France)
OSTI Identifier:
6460374
Resource Type:
Journal Article
Journal Name:
J. Med. Chem.; (United States)
Additional Journal Information:
Journal Volume: 32:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYSTAMINE; RADIOSENSITIVITY EFFECTS; RADIOPROTECTIVE SUBSTANCES; COMPARATIVE EVALUATIONS; CHEMICAL PREPARATION; MICE; AMINES; ANIMALS; DRUGS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RODENTS; SYNTHESIS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Oiry, J, Pue, J Y, Imbach, J L, Fatome, M, and Sentenac-Roumanou, H. Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives. United States: N. p., 1989. Web. doi:10.1021/jm00122a004.
Oiry, J, Pue, J Y, Imbach, J L, Fatome, M, & Sentenac-Roumanou, H. Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives. United States. https://doi.org/10.1021/jm00122a004
Oiry, J, Pue, J Y, Imbach, J L, Fatome, M, and Sentenac-Roumanou, H. 1989. "Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives". United States. https://doi.org/10.1021/jm00122a004.
@article{osti_6460374,
title = {Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives},
author = {Oiry, J and Pue, J Y and Imbach, J L and Fatome, M and Sentenac-Roumanou, H},
abstractNote = {Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).},
doi = {10.1021/jm00122a004},
url = {https://www.osti.gov/biblio/6460374}, journal = {J. Med. Chem.; (United States)},
number = ,
volume = 32:2,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 1989},
month = {Wed Feb 01 00:00:00 EST 1989}
}