Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives
Abstract
Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
- Authors:
- Publication Date:
- Research Org.:
- Universite des Sciences et Techniques du Languedoc, Montpellier (France)
- OSTI Identifier:
- 6460374
- Resource Type:
- Journal Article
- Journal Name:
- J. Med. Chem.; (United States)
- Additional Journal Information:
- Journal Volume: 32:2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYSTAMINE; RADIOSENSITIVITY EFFECTS; RADIOPROTECTIVE SUBSTANCES; COMPARATIVE EVALUATIONS; CHEMICAL PREPARATION; MICE; AMINES; ANIMALS; DRUGS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RODENTS; SYNTHESIS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
Citation Formats
Oiry, J, Pue, J Y, Imbach, J L, Fatome, M, and Sentenac-Roumanou, H. Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives. United States: N. p., 1989.
Web. doi:10.1021/jm00122a004.
Oiry, J, Pue, J Y, Imbach, J L, Fatome, M, & Sentenac-Roumanou, H. Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives. United States. https://doi.org/10.1021/jm00122a004
Oiry, J, Pue, J Y, Imbach, J L, Fatome, M, and Sentenac-Roumanou, H. 1989.
"Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives". United States. https://doi.org/10.1021/jm00122a004.
@article{osti_6460374,
title = {Synthesis and radioprotective activity of dipeptide cysteamine and cystamine derivatives},
author = {Oiry, J and Pue, J Y and Imbach, J L and Fatome, M and Sentenac-Roumanou, H},
abstractNote = {Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as candidate radioprotector agents. Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate. One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).},
doi = {10.1021/jm00122a004},
url = {https://www.osti.gov/biblio/6460374},
journal = {J. Med. Chem.; (United States)},
number = ,
volume = 32:2,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 1989},
month = {Wed Feb 01 00:00:00 EST 1989}
}
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