Fluosol and oxygen breathing as an adjuvant to radiation therapy in the treatment of locally advanced non-small cell carcinoma of the lung: Results of a phase I/II study

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90140-F· OSTI ID:6444211

Lustig, R; Lowe, N; Prosnitz, L; Spaulding, M; Cohen, M; Stitt, J; Brannon, R ^[1]

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1. Robert Wood Johnson Medical School, Camden, NJ (USA)

Fluosol, a perflourcarbon emulsion, has the ability to carry oxygen in solution. In conjunction with oxygen breathing and radiation, fluosol has been shown in animal models to enhance local tumor control. In September 1985, a Phase I/II Study was instituted to evaluate the effect of this adjuvant therapy with radiation in non-small cell carcinomas of the lung. Of the 49 patients administered Fluosol, 34 mild moderate adverse reactions were noted in 22 patients to either the test dose/infusion or post infusion. Flushing, dyspnea and hypertension and chills and/or fever were the typical symptoms. Transient elevation of blood chemistries were noted in some patients. Six patients had transient depression of WBC counts and two patients had transient depression of platelets. None of these altered treatment. Forty-five patients received Fluosol of which 34 completed the planned therapy. Six patients were diagnosed with metastatic disease during therapy and three patients died of their disease during treatment. Radiation therapy was administered at a daily fraction of 165 to 200 cGy per fraction to a total dose of 5940 to 6800 cGy.

• OSTI ID: 6444211
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 19:1; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
FREONS
RADIOSENSITIVITY EFFECTS
LUNGS
CARCINOMAS
COMBINED THERAPY
EMULSIONS
OXYGEN
PATIENTS
BODY
COLLOIDS
DISEASES
DISPERSIONS
ELEMENTS
HALOGENATED ALIPHATIC HYDROCARBONS
NEOPLASMS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)