In vivo and in vitro radiosensitivities ofnewly established mouse ascites tumors

Journal Article · Sun Mar 01 00:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575429· OSTI ID:6442742

Okamoto, M ^[1]; Tsuboi, A; Tsuchiya, T

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1. Univ. of Environmental and Occupational Health, Yahatanishi, Japan

The response of two newly established mouse mammary tumors to x irradiation in vitro and in vivo was studied by colony-forming assay in soft agar. Cells irradiated in vivo were more resistant than those irradiated in vitro. The D/sub 0/ values for in vitro irradiation were 112 rad at both exponential and stationary phases, while those for in vivo irradiation were 303 rad at exponential phase and 556 rad at stationary phase. This increase in D/sub 0/ value, which is greater than the OER, suggests that radiosensitivity in vivo cannot be explained only by hypoxia.

• OSTI ID: 6442742
• Journal Information: Radiat. Res.; (United States), Vol. 85:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOXIA
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
ASCITES TUMOR CELLS
EXPERIMENTAL NEOPLASMS
BIOASSAY
COLONY FORMATION
COMPARATIVE EVALUATIONS
IN VITRO
IN VIVO
MAMMARY GLANDS
MICE
RADIATION DOSES
RESPONSE MODIFYING FACTORS
X RADIATION
ANIMAL CELLS
ANIMALS
BODY
DOSES
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
MAMMALS
ORGANS
RADIATIONS
RODENTS
TUMOR CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)