Bone sarcoma characteristics and distribution in beagles injected with radium-226

Journal Article · Tue Mar 01 00:00:00 EST 1994 · Radiation Research; (United States)

DOI:https://doi.org/10.2307/3578711· OSTI ID:6440050

White, R G; Raabe, O G; Culbertson, M R; Parks, N J; Samuels, S J; Rosenblatt, L S ^[1]

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1. Univ. of California, Davis, CA (United States)

A total of 155 primary bone sarcomas were found in 131 of the 246 beagles injected with [sup 226]Ra and 5 primary bone sarcomas were found in 4 of the 158 unexposed controls. Of these 155 bone sarcomas, 146 (94%) were osteosarcomas and 9 were nonosteosarcomas. An additional 31 primary bone sarcomas (28 osteosarcomas) developed in 44 dogs terminated from the main study because of limb amputation for bone sarcoma. Nonosteosarcomas predominated in both the controls and the second lowest of six logarithmically increasing dose levels (there were no bone sarcomas in the lowest dose group). Osteosarcomas predominated at the higher dose levels, and incidence tended to increase as dose increased. The 146 osteosarcomas were distributed quite evenly between males and females (72:74). Of the 9 nonosteosarcomas, 6 occurred in males and 3 in females. The ratio of bone sarcomas of the appendicular skeleton to those in the axial skeleton was 110:45, with osteosarcomas occurring more often in the appendicular skeleton (108:38). Cases of multiple primary bone sarcomas in dogs injected with [sup 226]Ra were found only in the four highest dose groups. Amputations were performed on 44 of the 96 dogs (94 injected and 2 unexposed) that developed appendicular bone sarcomas. A statistical study of the distribution of bone sarcomas among 16 separate bone groups showed a statistically significant correlation to cancellous skeletal surface, but the variability among bone groups was too large for this relationship to be of real predictive value. it is postulated that the distribution of bone sarcomas reflects primarily the relative cell division rates in the bone groups and secondarily the radiation dose distribution, with the highest occurrence of bone sarcoma in the humeri, pelvis, femora and tibiae/fibular tarsal, and no occurrence in the coccygeal vertebrae, sternum, forepaws or hindpaws. 16 refs., 5 figs., 4 tabs.

• DOE Contract Number: AC03-76SF00472; FG03-89ER60914
• OSTI ID: 6440050
• Journal Information: Radiation Research; (United States), Vol. 137:3; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAGLES
BIOLOGICAL RADIATION EFFECTS
SKELETON
BONE TISSUES
CELL DIVISION
RADIUM 226
DOSE-RESPONSE RELATIONSHIPS
SARCOMAS
BIOLOGICAL LOCALIZATION
SEX DEPENDENCE
DISEASE INCIDENCE
OSTEOSARCOMAS
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBON 14 DECAY RADIOISOTOPES
CONNECTIVE TISSUE
DISEASES
DOGS
EVEN-EVEN NUCLEI
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIUM ISOTOPES
SKELETAL DISEASES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals