Chelation in metal intoxication. XVIII. Combined effects of thiamine and calcium disodium versenate on lead toxicity

Journal Article · Mon Jan 06 00:00:00 EST 1986 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(86)90276-6· OSTI ID:6425577

Flora, S J.S.; Singh, S; Tandon, S K

Calcium disodium ethylenediaminetetra-acetate (Ca-Na/sub 2/EDTA; Versenate) was more effective than thiamine (vitamin B/sub 1/) in enhancing the urinary excretion of lead, reducing tissue lead and restoring lead induced biochemical alterations in rats. However, the combination of CaNa/sub 2/EDTA and vitamin B/sub 1/ enhanced the beneficial effect of CaNa/sub 2/EDTA in lead intoxication and was particularly effective in reducing the brain concentration of lead. 18 references, 1 figure, 2 tables.

• Research Organization: Industrial Toxicology Research Centre, Lucknow, India
• OSTI ID: 6425577
• Journal Information: Life Sci.; (United States), Vol. 38:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EDTA
BIOLOGICAL EFFECTS
LEAD
RENAL CLEARANCE
TOXICITY
VITAMIN B GROUP
BRAIN
CALCIUM COMPOUNDS
EXPERIMENTAL DATA
RATS
SODIUM COMPOUNDS
SYNERGISM
TISSUE DISTRIBUTION
ALKALI METAL COMPOUNDS
ALKALINE EARTH METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CLEARANCE
DATA
DISTRIBUTION
ELEMENTS
EXCRETION
INFORMATION
MAMMALS
METALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
VITAMINS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)