Evaluation of brain edema using magnetic resonance proton relaxation times

Fu, Y; Tanaka, K; Nishimura, S

Title: Evaluation of brain edema using magnetic resonance proton relaxation times

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Abstract

Experimental and clinical studies on the evaluation of water content in cases of brain edema were performed in vivo, using MR proton relaxation times (longitudinal relaxation time, T1; transverse relaxation time, T2). Brain edema was produced in the white matter of cats by the direct infusion method. The correlations between proton relaxation times obtained from MR images and the water content of white matter were studied both in autoserum-infused cats and in saline-infused cats. The correlations between T1 as well as T2 and the water content in human vasogenic brain edema were also examined and compared with the data obtained from the serum group. T1 and T2 showed good correlations with the water content of white matter not only in the experimental animals but also in the clinical cases. The quality of the edema fluid did not influence relaxation time and T1 seemed to represent almost solely the water content of the tissue. T2, however, was affected by the nature of existence of water and was more sensitive than T1 in detecting extravasated edema fluid. It seems feasible therefore to evaluate the water content of brain edema on the basis of T1 values.

Authors:

Fu, Y; Tanaka, K; Nishimura, S ^[1]

Baba Memorial Hospital, Osaka (Japan)

Publication Date:: Mon Jan 01 00:00:00 EST 1990

OSTI Identifier:: 6422039

Resource Type:: Journal Article

Journal Name:: Advances in Neurology; (USA)

Additional Journal Information:: Journal Volume: 52; Journal ID: ISSN 0091-3952

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; NMR IMAGING; NERVOUS SYSTEM DISEASES; DIAGNOSIS; CATS; EDEMA; MAN; NUCLEAR MAGNETIC RESONANCE; PROTONS; ANIMALS; BARYONS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTARY PARTICLES; FERMIONS; HADRONS; MAGNETIC RESONANCE; MAMMALS; NERVOUS SYSTEM; NUCLEONS; ORGANS; PATHOLOGICAL CHANGES; PRIMATES; RESONANCE; SYMPTOMS; VERTEBRATES; 550600* - Medicine

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                    Fu, Y, Tanaka, K, and Nishimura, S. Evaluation of brain edema using magnetic resonance proton relaxation times.  United States: N. p., 1990. 
        Web.

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                    Fu, Y, Tanaka, K, & Nishimura, S. Evaluation of brain edema using magnetic resonance proton relaxation times.  United States.

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                    Fu, Y, Tanaka, K, and Nishimura, S. 1990.  
        "Evaluation of brain edema using magnetic resonance proton relaxation times".  United States.

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@article{osti_6422039,

  title        = {Evaluation of brain edema using magnetic resonance proton relaxation times},

  author       = {Fu, Y and Tanaka, K and Nishimura, S},

  abstractNote = {Experimental and clinical studies on the evaluation of water content in cases of brain edema were performed in vivo, using MR proton relaxation times (longitudinal relaxation time, T1; transverse relaxation time, T2). Brain edema was produced in the white matter of cats by the direct infusion method. The correlations between proton relaxation times obtained from MR images and the water content of white matter were studied both in autoserum-infused cats and in saline-infused cats. The correlations between T1 as well as T2 and the water content in human vasogenic brain edema were also examined and compared with the data obtained from the serum group. T1 and T2 showed good correlations with the water content of white matter not only in the experimental animals but also in the clinical cases. The quality of the edema fluid did not influence relaxation time and T1 seemed to represent almost solely the water content of the tissue. T2, however, was affected by the nature of existence of water and was more sensitive than T1 in detecting extravasated edema fluid. It seems feasible therefore to evaluate the water content of brain edema on the basis of T1 values.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6422039},
  journal      = {Advances in Neurology; (USA)},

  issn         = {0091-3952},

  number       = ,

  volume       = 52,

  place        = {United States},

  year         = {Mon Jan 01 00:00:00 EST 1990},

  month        = {Mon Jan 01 00:00:00 EST 1990}

}

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