Atrial natriuretic peptide stimulates salt secretion by shark rectal gland by releasing VIP
Salt secretion by the isolated perfused rectal gland of the spiny dogfish shark, Squalus acanthias, is stimulated by synthetic rat atrial natriuretic peptide (ANP II) as well as extracts of shark heart, but not by 8-bromo-cyclic guanosine 5'-monophosphate. Cardiac peptides have no effect on isolated rectal gland cells or perfused tubules, suggesting that stimulation requires an intact gland. The stimulation of secretion by ANP II is eliminated by maneuvers that block neurotransmitter release. Cardiac peptides stimulate the release of vasoactive intestinal peptide (VIP), known to be present in rectal glands nerves, into the venous effluent of perfused glands in parallel with their stimulation of salt secretion, but the release of VIP induced by ANP II is prevented by perfusion with procaine. VIP was measured by radioimmunoassay. Cardiac peptides thus appear to regulate rectal gland secretion by releasing VIP from neural stores within the gland. It is possible that other physiological effects of these hormones might be explained by an action to enhanced local release of neurotransmitters.
- Research Organization:
- Harvard Medical School, Boston, MA
- OSTI ID:
- 6410444
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
PEPTIDES
RADIOIMMUNOASSAY
SALTS
SECRETION
CALCIUM COMPOUNDS
HEART
HORMONES
IODINE 125
MAGNESIUM COMPOUNDS
ORGANS
PHYSIOLOGY
ULTRAFILTRATION
VERTEBRATES
ALKALINE EARTH METAL COMPOUNDS
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ELECTRON CAPTURE RADIOISOTOPES
FILTRATION
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INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
SEPARATION PROCESSES
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
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