Maternal ethanol ingestion: effect on maternal and neonatal glucose balance
Abstract
Liver glycogen availability in the newborn is of major importance for the maintenance of postnatal blood glucose levels. This study examined the effect of maternal ethanol ingestion on maternal and neonatal glucose balance in the rate. Female rats were placed on 1) the Lieber-DeCarli liquid ethanol diet, 2) an isocaloric liquid pair-diet, or 3) an ad libitum rat chow diet at 3 wk before mating and throughout gestation. Blood and livers were obtained from dams and rat pups on gestational days 21 and 22. The pups were studied up to 6 h in the fasted state and up to 24 h in the fed state. Maternal ethanol ingestion significantly decreased litter size, birth weight, and growth. A significantly higher mortality during the early postnatal period was seen in the prenatal ethanol exposed pups. Ethanol significantly decreased fed maternal liver glycogen stores but not maternal plasma glucose levels. The newborn rats from ethanol ingesting dams also had significantly decreased liver glycogen stores. Despite mobilizing their available glycogen, these prenatal ethanol exposed pups became hypoglycemic by 6 h postnatal. This was more marked in the fasted pups. Ethanol did not affect maternal nor neonatal plasma insulin levels. Thus maternal ethanol ingestion reducesmore »
- Authors:
- Publication Date:
- Research Org.:
- Loyola Univ., Maywood, IL
- OSTI Identifier:
- 6409659
- Resource Type:
- Journal Article
- Journal Name:
- Am. J. Physiol.; (United States)
- Additional Journal Information:
- Journal Volume: 251:2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; ETHANOL; BIOLOGICAL EFFECTS; INGESTION; GLUCOSE; BLOOD CHEMISTRY; GLYCOGEN; INSULIN; RADIOIMMUNOASSAY; LIVER; MORTALITY; NEONATES; RATS; ALCOHOLS; ALDEHYDES; ANIMALS; BODY; CARBOHYDRATES; DIGESTIVE SYSTEM; GLANDS; HEXOSES; HORMONES; HYDROXY COMPOUNDS; IMMUNOASSAY; IMMUNOLOGY; INTAKE; ISOTOPE APPLICATIONS; MAMMALS; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; POLYSACCHARIDES; RADIOASSAY; RADIOIMMUNOLOGY; RODENTS; SACCHARIDES; TRACER TECHNIQUES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550601 - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Witek-Janusek, L. Maternal ethanol ingestion: effect on maternal and neonatal glucose balance. United States: N. p., 1986.
Web.
Witek-Janusek, L. Maternal ethanol ingestion: effect on maternal and neonatal glucose balance. United States.
Witek-Janusek, L. 1986.
"Maternal ethanol ingestion: effect on maternal and neonatal glucose balance". United States.
@article{osti_6409659,
title = {Maternal ethanol ingestion: effect on maternal and neonatal glucose balance},
author = {Witek-Janusek, L},
abstractNote = {Liver glycogen availability in the newborn is of major importance for the maintenance of postnatal blood glucose levels. This study examined the effect of maternal ethanol ingestion on maternal and neonatal glucose balance in the rate. Female rats were placed on 1) the Lieber-DeCarli liquid ethanol diet, 2) an isocaloric liquid pair-diet, or 3) an ad libitum rat chow diet at 3 wk before mating and throughout gestation. Blood and livers were obtained from dams and rat pups on gestational days 21 and 22. The pups were studied up to 6 h in the fasted state and up to 24 h in the fed state. Maternal ethanol ingestion significantly decreased litter size, birth weight, and growth. A significantly higher mortality during the early postnatal period was seen in the prenatal ethanol exposed pups. Ethanol significantly decreased fed maternal liver glycogen stores but not maternal plasma glucose levels. The newborn rats from ethanol ingesting dams also had significantly decreased liver glycogen stores. Despite mobilizing their available glycogen, these prenatal ethanol exposed pups became hypoglycemic by 6 h postnatal. This was more marked in the fasted pups. Ethanol did not affect maternal nor neonatal plasma insulin levels. Thus maternal ethanol ingestion reduces maternal and neonatal liver glycogen stores and leads to postnatal hypoglycemia in the newborn rat.},
doi = {},
url = {https://www.osti.gov/biblio/6409659},
journal = {Am. J. Physiol.; (United States)},
number = ,
volume = 251:2,
place = {United States},
year = {Fri Aug 01 00:00:00 EDT 1986},
month = {Fri Aug 01 00:00:00 EDT 1986}
}