Enhancement of artificial lung metastases by misonidazole

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90356-0· OSTI ID:6407716

Rockwell, S; Nierenburg, M; Irvin, C G

The effect of treatment with the hypoxic cell radiosensitizer misonidazole on the formation of artificial lung metastases was examined. Both single treatments with large doses of misonidazole and fractionated treatments with smaller doses of misonidazole were found to increase the number of lung tumors developing after intravenous injection of EMT6 mouse mammary carcinoma cells. The immunologic and physiologic effects of the nitroimidazole were postulated to be responsible for the enhancement of lung tumor formation.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 6407716
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
METASTASES
GROWTH
MISONIDAZOLE
RADIOSENSITIVITY EFFECTS
TUMOR CELLS
INTRAVENOUS INJECTION
CARCINOMAS
LUNGS
MICE
RADIOTHERAPY
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BODY
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INJECTION
INTAKE
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOLOGY
RADIOSENSITIZERS
RESPIRATORY SYSTEM
RODENTS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals