Evaluation of octanol-water partition coefficients using capillary gas chromatography with cold on-column injection

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Anal. Lett.; (United States)

DOI:https://doi.org/10.1080/00032718608066246· OSTI ID:6400741

Haky, J E; Leja, B

A general procedure is described for the determination of the octanol-water partition coefficients (log P) of very lipophilic compounds by the shake flask method, employing the analytical technique of capillary gas chromatography with cold on-column injection. The solute and an internal reference with a known log P value are partitioned between the layers of an octanol-water mixture and their relative concentrations are determined by analysis of each phase, using highly standardized chromatographic conditions. The overall method is demonstrated to be convenient, reproducible, and useful for the determination of the partition coefficients of a wide variety of compounds with log P values as high as 5.7. 14 references, 1 figure, 1 table.

• Research Organization: Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, MI
• OSTI ID: 6400741
• Journal Information: Anal. Lett.; (United States), Vol. 19:1-2
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
OCTANOLS
PARTITION
WATER
CAPILLARY FLOW
EXPERIMENTAL DATA
GAS CHROMATOGRAPHY
PHASE STUDIES
SOLUTIONS
ALCOHOLS
CHROMATOGRAPHY
DATA
DISPERSIONS
FLUID FLOW
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
MIXTURES
NUMERICAL DATA
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
SEPARATION PROCESSES
400301* - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)
400201 - Chemical & Physicochemical Properties