Changes in the nuclear uptake and retention of /sup 3/H-estrogen in gonadotrophs and lactotrophs as a function of age
A quantitative autoradiographic immunocytochemical study was performed in which the nuclear uptake and retention of /sup 3/H-estradiol (/sup 3/H-E2) by luteinizing hormone (LH) and prolactin (PRL) cells was examined in 19-21-year-old baboons. /sup 3/H-E2 concentrating cells were found in all of the three lobes of the pituitary in varying percentages. Approximately 80% of PRL cells and nearly 100% of LH cells were labeled. A count of the number of silver grains over nuclei revealed a marked variation of the accumulation of /sup 3/H-E2 by LH cells and to a lesser extent in PRL cells. These results suggest functional heterogeneity among LH and PRL cells. The present results are discussed in relation to the physiological state of old animals.
- Research Organization:
- Univ. of Texas Health Science Center, San Antonio
- OSTI ID:
- 6388761
- Journal Information:
- Anat. Rec.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ESTRADIOL
UPTAKE
PITUITARY GLAND
AUTORADIOGRAPHY
TRITIUM COMPOUNDS
AGE DEPENDENCE
APES
CYTOCHEMISTRY
LH
LTH
ANIMALS
BIOCHEMISTRY
BODY
CHEMISTRY
ENDOCRINE GLANDS
ESTRANES
ESTROGENS
GLANDS
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
STEROID HORMONES
STEROIDS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics