Metabolites of 1,2,3,4-tetrachlorobenzene in monkey urine
(/sup 14/C(U))-Labeled 1,2,3,4-tetrachlorobenzene was administered orally to squirrel monkeys. Urine was collected from these animals, pooled and analyzed for metabolites by thin-layer chromatography, high-performance liquid chromatography, and gas chromatography-mass spectroscopy. N-Acetyl-s(2,3,4,5-tetrachlorophenyl) cysteine was shown to be the major metabolite and accounted for 85% of the radioactivity found in urine. A minor metabolite was identified at 2,3,4,5-tetrachlorophenol. This study demonstrates for the first time that an N-acetyl cysteine conjugate has been isolated and identified as metabolite of a chlorinated benzene. This pattern of chlorobenzene metabolism is significantly different from the one obtained with the rat and rabbit, where tetrachlorophenols constitute the major metabolites.
- Research Organization:
- Environmental Health Directorate, Ottawa, Ontario
- OSTI ID:
- 6380200
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 15:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
METABOLISM
MONKEYS
BIOLOGICAL VARIABILITY
CARBON 14 COMPOUNDS
CHROMATOGRAPHY
MASS SPECTROSCOPY
METABOLITES
ORAL ADMINISTRATION
TRACER TECHNIQUES
URINE
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
HALOGENATED AROMATIC HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
SEPARATION PROCESSES
SPECTROSCOPY
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques