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Title: Molecular and cellular markers of toxicity in the Japanese Medaka @

The Japanese Medaka (Oryzias latipes) has been recommended for use as a model organism to detect carcinogenic, teratogenic, cytotoxic, and genotoxic compounds in aquatic systems. Because a long latent period often occurs between initial contact with deleterious chemicals and subsequent expression of the pathology, we are investigating early biologically-relevant responses that can be used as genotoxicity markers of exposure and effect. This project focuses on the development of genotoxic bioassays and experimental protocols for exposing Japanese Medaka to genotoxic compounds. 21 refs., 8 figs, 2 tabs.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
6360811
Report Number(s):
CONF-9008165-1
ON: DE91001923; CNN: Project 1016-B047-A1
Resource Type:
Conference
Resource Relation:
Conference: 3. annual carcinogencity research review meeting, Frederick, MD (USA), 14-15 Aug 1990
Research Org:
Oak Ridge National Lab., TN (USA)
Sponsoring Org:
DOD; DOE/ER
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BENZOPYRENE; TOXICITY; FISHES; BIOASSAY; BIOLOGICAL INDICATORS; BIOLOGICAL MARKERS; DNA; ENVIRONMENTAL EXPOSURE; REPRODUCTION; STRAND BREAKS; ANIMALS; AQUATIC ORGANISMS; AROMATICS; CONDENSED AROMATICS; HYDROCARBONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology; 550200 -- Biochemistry; 551000 -- Physiological Systems