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Title: Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116

Abstract

Recent studies have demonstrated that the majority of muscarinic receptors in rabbit peripheral lung homogenates bind pirenzepine with high affinity (putative M1 subtype). In experiments of AF-DX 116 inhibiting (TH)(-)quinuclidinyl benzilate or (TH)pirenzepine, the authors found similar inhibitory constants for AF-DX 116 binding in rat heart and rabbit peripheral lung that were 4-fold smaller (i.e. of higher affinity) than the inhibitory constant for rat cerebral cortex. This results demonstrates heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex. 20 references, 1 figure, 2 tables.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Arizona, Tucson
OSTI Identifier:
6360430
Resource Type:
Journal Article
Journal Name:
Life Sci.; (United States)
Additional Journal Information:
Journal Volume: 41:4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SYMPATHOMIMETICS; BIOCHEMICAL REACTION KINETICS; RECEPTORS; CEREBRAL CORTEX; EXPERIMENTAL DATA; LUNGS; RABBITS; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CEREBRUM; DATA; DRUGS; INFORMATION; ISOTOPE APPLICATIONS; KINETICS; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANS; REACTION KINETICS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Bloom, J W, Halonen, M, Seaver, N A, and Yamamura, H I. Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116. United States: N. p., 1987. Web. doi:10.1016/0024-3205(87)90226-8.
Bloom, J W, Halonen, M, Seaver, N A, & Yamamura, H I. Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116. United States. https://doi.org/10.1016/0024-3205(87)90226-8
Bloom, J W, Halonen, M, Seaver, N A, and Yamamura, H I. 1987. "Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116". United States. https://doi.org/10.1016/0024-3205(87)90226-8.
@article{osti_6360430,
title = {Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116},
author = {Bloom, J W and Halonen, M and Seaver, N A and Yamamura, H I},
abstractNote = {Recent studies have demonstrated that the majority of muscarinic receptors in rabbit peripheral lung homogenates bind pirenzepine with high affinity (putative M1 subtype). In experiments of AF-DX 116 inhibiting (TH)(-)quinuclidinyl benzilate or (TH)pirenzepine, the authors found similar inhibitory constants for AF-DX 116 binding in rat heart and rabbit peripheral lung that were 4-fold smaller (i.e. of higher affinity) than the inhibitory constant for rat cerebral cortex. This results demonstrates heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex. 20 references, 1 figure, 2 tables.},
doi = {10.1016/0024-3205(87)90226-8},
url = {https://www.osti.gov/biblio/6360430}, journal = {Life Sci.; (United States)},
number = ,
volume = 41:4,
place = {United States},
year = {Mon Jul 27 00:00:00 EDT 1987},
month = {Mon Jul 27 00:00:00 EDT 1987}
}