Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116

Journal Article · Mon Jul 27 00:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90226-8· OSTI ID:6360430

Bloom, J W; Halonen, M; Seaver, N A; Yamamura, H I

Recent studies have demonstrated that the majority of muscarinic receptors in rabbit peripheral lung homogenates bind pirenzepine with high affinity (putative M1 subtype). In experiments of AF-DX 116 inhibiting (TH)(-)quinuclidinyl benzilate or (TH)pirenzepine, the authors found similar inhibitory constants for AF-DX 116 binding in rat heart and rabbit peripheral lung that were 4-fold smaller (i.e. of higher affinity) than the inhibitory constant for rat cerebral cortex. This results demonstrates heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex. 20 references, 1 figure, 2 tables.

• Research Organization: Univ. of Arizona, Tucson
• OSTI ID: 6360430
• Journal Information: Life Sci.; (United States), Vol. 41:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SYMPATHOMIMETICS
BIOCHEMICAL REACTION KINETICS
RECEPTORS
CEREBRAL CORTEX
EXPERIMENTAL DATA
LUNGS
RABBITS
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
DATA
DRUGS
INFORMATION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques