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Title: Use of short-term test systems for the prediction of the hazard represented by potential chemical carcinogens

It has been hypothesized that results from short-term bioassays will ultimately provide information that will be useful for human health hazard assessment. Historically, the validity of the short-term tests has been assessed using the framework of the epidemiologic/medical screens. In this context, the results of the carcinogen (long-term) bioassay is generally used as the standard. However, this approach is widely recognized as being biased and, because it employs qualitative data, cannot be used to assist in isolating those compounds which may represent a more significant toxicologic hazard than others. In contrast, the goal of this research is to address the problem of evaluating the utility of the short-term tests for hazard assessment using an alternative method of investigation. Chemicals were selected mostly from the list of carcinogens published by the International Agency for Research on Carcinogens (IARC); a few other chemicals commonly recognized as hazardous were included. Tumorigenicity and mutagenicity data on 52 chemicals were obtained from the Registry of Toxic Effects of Chemical Substances (RTECS) and were analyzed using a relative potency approach. The data were evaluated in a format which allowed for a comparison of the ranking of the mutagenic relative potencies of the compounds (as estimated usingmore » short-term data) vs. the ranking of the tumorigenic relative potencies (as estimated from the chronic bioassays). Although this was a preliminary investigation, it offers evidence that the short-term tests systems may be of utility in ranking the hazards represented by chemicals which may contribute to increased carcinogenesis in humans as a result of occupational or environmental exposures. 177 refs., 8 tabs.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6358489
Report Number(s):
ORNL/TM-11413
ON: DE91005643; TRN: 91-002551
DOE Contract Number:
AC05-84OR21400
Resource Type:
Technical Report
Research Org:
Oak Ridge National Lab., TN (USA)
Sponsoring Org:
DOE/ER
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGENS; HEALTH HAZARDS; NEOPLASMS; EPIDEMIOLOGY; ACUTE EXPOSURE; BIOASSAY; CARCINOGENESIS; CHRONIC EXPOSURE; HUMAN POPULATIONS; TOXICITY; DISEASES; HAZARDS; PATHOGENESIS; POPULATIONS 560300* -- Chemicals Metabolism & Toxicology