Exposure to low levels of hydrogen sulfide elevates circulating glucose in maternal rats

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Journal of Toxicology and Environmental Health; (USA)

DOI:https://doi.org/10.1080/15287399009531436· OSTI ID:6358091

Hayden, L J; Goeden, H; Roth, S H ^[1]

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1. Univ. of Calgary, Alberta (Canada)

Although the lethal effect of hydrogen sulfide (H{sub 2}S) has long been known, the results of exposure to low levels of H{sub 2}S have not been well documented. Rat dams and pups were exposed to low levels of H{sub 2}S (less than or equal to 75 ppm) from d 1 of gestation until d 21 postpartum and analyzed for changes in circulating enzymatic activity and metabolites. Blood glucose was significantly elevated in maternal blood on d 21 postpartum at all exposure levels. This increase in glucose was accompanied by a possible decrease in serum triglyceride in the pups and in the dams on d 21 postpartum. There was no evidence of alterations in serum alkaline phosphatase, lactate dehydrogenase, or serum glutamate oxaloacetate transaminase.

• OSTI ID: 6358091
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Vol. 31:1; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GLUCOSE
BIOSYNTHESIS
HYDROGEN SULFIDES
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
METABOLISM
METABOLITES
RATS
TRIGLYCERIDES
ALDEHYDES
ANIMALS
CARBOHYDRATES
CHALCOGENIDES
ESTERS
HEXOSES
HYDROGEN COMPOUNDS
LIPIDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
RODENTS
SACCHARIDES
SULFIDES
SULFUR COMPOUNDS
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology