PCP-induced alterations in cerebral glucose utilization in rat brain: blockade by metaphit, a PCP-receptor-acylating agent

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Synapse; (United States)

DOI:https://doi.org/10.1002/syn.890010514· OSTI ID:6353843

Tamminga, C A; Tanimoto, K; Kuo, S; Chase, T N; Contreras, P C; Rice, K C; Jackson, A E; O'Donohue, T L

The effects of phencyclidine (PCP) on regional cerebral glucose utilization was determined by using quantitative autoradiography with (/sup 14/C)-2-deoxyglucose. PCP increased brain metabolism in selected areas of cortex, particularly limbic, and in the basal ganglia and thalamus, whereas the drug decreased metabolism in areas related to audition. These results are consistent with the known physiology of central PCP neurons and may help to suggest brain areas involved in PCP-mediated actions. Moreover, based on the behavioral similarities between PCP psychosis and an acute schizophrenic episode, these data may be relevant to the understanding of schizophrenia. The PCP-receptor-acylating agent, metaphit, blocked most of these PCP actions. In addition, metaphit by itself was found to diminish glucose utilization rather uniformly throughout brain. These results indicate an antagonist effect of metaphit on the PCP system and suggest a widespread action of metaphit, putatively at a PCP-related site, possibly in connection with the N-methyl-D-aspartate (NMDA) receptor.

• Research Organization: Experimental Therapeutics Branch, NINCDS, Bethesda, MD (USA)
• OSTI ID: 6353843
• Journal Information: Synapse; (United States), Vol. 1:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GLUCOSE
METABOLISM
NERVOUS SYSTEM DISEASES
PATHOGENESIS
PIPERIDINES
BIOCHEMICAL REACTION KINETICS
ACYLATION
AUTORADIOGRAPHY
BRAIN
CARBON 14 COMPOUNDS
NERVE CELLS
RATS
ALDEHYDES
AMINES
ANIMAL CELLS
ANIMALS
AZINES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
DISEASES
HETEROCYCLIC COMPOUNDS
HEXOSES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
REACTION KINETICS
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550901 - Pathology- Tracer Techniques