Reduced progesterone and altered cotyledonary prostaglandin values induced by locoweed (Astragalus lentiginosus) in sheep

Journal Article · Sun Sep 01 00:00:00 EDT 1985 · Am. J. Vet. Res.; (United States)

OSTI ID:6335914

Ellis, L C; James, L F; McMullen, R W; Panter, K E

Feeding 300 or 400 g of dried spotted locoweed, Astragalus lentiginosus per day to 11 pregnant Columbia ewes from the 20th to the 50th days of their gestations resulted in dead and edematous fetuses. Aspartate aminotransferase values were increased, whereas serum progesterone values were significantly diminished in a dose-dependent manner by locoweed ingestion. Cotyledonary 6-keto-prostaglandin (PG)F1 alpha (400 g/day only) and PGF2 alpha (300 and 400 g/day) values were significantly increased, whereas PGE values were not affected by the treatment. Alterations in PG values in these sheep may be a mechanism for altering corpus luteum function and inducing fetal death, which would ultimately result in abortion.

• Research Organization: Utah State Univ., Logan
• OSTI ID: 6335914
• Journal Information: Am. J. Vet. Res.; (United States), Vol. 9
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
PLANTS
INGESTION
PROGESTERONE
BIOCHEMISTRY
PROSTAGLANDINS
AMINOTRANSFERASES
PLACENTA
PREGNANCY
RADIOIMMUNOASSAY
SHEEP
TRITIUM COMPOUNDS
ANIMALS
CHEMISTRY
DOMESTIC ANIMALS
ENZYMES
FETAL MEMBRANES
HORMONES
IMMUNOLOGY
INTAKE
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
PREGNANES
RADIOASSAY
RADIOIMMUNOLOGY
RUMINANTS
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
TRANSFERASES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
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