Effect of altered thyroid status on the transport of hepatobiliary radiopharmaceuticals
The effect of induced hypothyroidism (by feeding an antithyroid drug-propylthiouracil) on the transport and clearance of the routinely used hepatobiliary radiopharmaceuticals--radioiodinated iodine- T (131I) rose bengal and technetium-99m-N-(4-n-butylphenylcarbamoylmethyl) iminodiacetate, was studied in the rats. Hypothyroidism was associated with depressed growth and retarded clearance of these radiotracers from the in vivo system. Treatment of the hypothyroid rats with thyroxine (2-5 micrograms/100 g b.w. day) for 6 wk, restored these parameters towards normal values. These data suggest that delayed clearance of these hepatobiliary tracers could be related to reduced metabolic rate accompanied with the hypotonia and hypomotility of intestine normally observed in the hypothyroid state.
- Research Organization:
- Bhabha Atomic Research Centre, Parel, India
- OSTI ID:
- 6334803
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 10
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison of /sup 99m/Tc-N-pyridoxyl-5-methyltryptophan and /sup 99m/Tc-N-(3-bromo-2,4,6-trimethylacetanilide)-iminodiacetate as hepatobiliary radiopharmaceuticals in rats
Technetium-99m-labeled N-(2,6-dimethylphenylcarbamoylmethyl) iminodiacetic acid (/sup 99m/Tc HIDA): a new radiopharmaceutical for hepatobiliary imaging studies. [/sup 14/C, /sup 113/Sn]
Related Subjects
HYPOTHYROIDISM
BIOLOGICAL EFFECTS
RADIOPHARMACEUTICALS
RETENTION
UPTAKE
ACETATES
BILIARY TRACT
IMINES
IODINE 131
ISOMERIC NUCLEI
LIVER
RATS
ROSE BENGAL
TECHNETIUM 99
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
DYES
ENDOCRINE DISEASES
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INDICATORS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
REAGENTS
RODENTS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics