Effects of thiuram, disulfiram and a trace element mixture on the incidence of tibial dyschondroplasia in chickens
Two experiments were conducted to determine the effect of dietary addition of 30 ppm of thiuram or disulfiram on the development of tibial dyschondroplasia (a large mass of cartilage in the proximal end of the tibia) in chicks in the presence and absence of trace element supplementation: B, Ni, Al, Sr, Br, V, Si, Sn, Cr, F, Mo, Li, Mn, Zn, Fe, Cu and I. In two experiments, the incidence and severity of tibial dyschondroplasia were lower in chicks fed the diet containing the trace element supplement than in those fed the basal diet. Adding thiuram or disulfiram to the diet caused a significantly higher incidence and severity of tibial dyschondroplasia in chicks regardless of the presence or absence of the trace element supplement. In a third experiment not involving thiuram or disulfiram the addition of trace elements had no significant effect on tibial dyschondroplasia. Adding thiuram or disulfiram to the diet in a fourth experiment lowered the absorption of /sup 47/Ca from the gastrointestinal tract but did not influence the biological half-life of /sup 47/Ca in the chick.
- Research Organization:
- Univ. of Georgia, Athens
- OSTI ID:
- 6326643
- Journal Information:
- J. Nutr.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CALCIUM
INTESTINAL ABSORPTION
CHICKENS
SKELETAL DISEASES
ELEMENTS
TOXICITY
ABSORPTION
ALUMINIUM
BIOLOGICAL HALF-LIFE
BORON
BROMINE
CALCIUM 47
CHROMIUM
COPPER
FLUORINE
IODINE
IRON
LITHIUM
MANGANESE
MOLYBDENUM
NICKEL
SILICON
STRONTIUM
TRACE AMOUNTS
TRACER TECHNIQUES
VANADIUM
ALKALI METALS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIRDS
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
FOWL
HALOGENS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
METALS
NONMETALS
NUCLEI
RADIOISOTOPES
SEMIMETALS
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
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