Stimulatory actions of bioflavenoids on tyrosine uptake into cultured bovine adrenal chromaffin cells

Journal Article · Fri Sep 28 00:00:00 EDT 1990 · Biochemical and Biophysical Research Communications; (USA)

DOI:https://doi.org/10.1016/0006-291X(90)90812-2· OSTI ID:6325846

Morita, K; Hamano, S; Oka, M; Teraoka, K ^[1]

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1. Tokushima Univ. School of Medicine (Japan)

The effects of flavenoids on L-({sup 14}C)tyrosine uptake into cultured adrenal chromaffin cells were examined. Flavone markedly stimulated tyrosine uptake into these cells in a manner dependent on its concentration. Apigenin also caused a moderate stimulatory action, but quercetin had no significant effect on the uptake. Flavone also stimulated the uptake of histidine, but did not affect the uptake of serine, lysine, or glutamic acid. These results are considered to propose the possibility that flavonoids may be able to stimulate the precursor uptake into the cells, resulting in an enhancement of the biogenic amine production.

• OSTI ID: 6325846
• Journal Information: Biochemical and Biophysical Research Communications; (USA), Vol. 171:3; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
FLAVENOIDS
BIOCHEMICAL REACTION KINETICS
TYROSINE
MEMBRANE TRANSPORT
ADRENAL GLANDS
ANIMAL CELLS
CARBON 14 COMPOUNDS
TRACER TECHNIQUES
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
ENDOCRINE GLANDS
GLANDS
HYDROXY ACIDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
REACTION KINETICS
550201* - Biochemistry- Tracer Techniques