Abdominal radiation causes bacterial translocation
The purpose of this study was to determine if a single dose of radiation to the rat abdomen leads to bacterial translocation into the mesenteric lymph nodes (MLN). A second issue addressed was whether translocation correlates with anatomic damage to the mucosa. The radiated group (1100 cGy) which received anesthesia also was compared with a control group and a third group which received anesthesia alone but no abdominal radiation. Abdominal radiation lead to 100% positive cultures of MLN between 12 hr and 4 days postradiation. Bacterial translocation was almost nonexistent in the control and anesthesia group. Signs of inflammation and ulceration of the intestinal mucosa were not seen until Day 3 postradiation. Mucosal damage was maximal by Day 4. Bacterial translocation onto the MLN after a single dose of abdominal radiation was not apparently dependent on anatomical, histologic damage of the mucosa.
- Research Organization:
- Univ. of Minnesota Medical School, Minneapolis (USA)
- OSTI ID:
- 6324305
- Journal Information:
- J. Surg. Res.; (United States), Vol. 46:2
- Country of Publication:
- United States
- Language:
- English
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ABDOMEN
ACUTE IRRADIATION
BACTERIA
TRANSLOCATION
MUCOUS MEMBRANES
BIOLOGICAL RADIATION EFFECTS
ANESTHESIA
INTESTINES
LYMPH NODES
MESENTERY
RATS
ACUTE EXPOSURE
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MEMBRANES
MICROORGANISMS
ORGANS
RADIATION EFFECTS
RODENTS
SEROUS MEMBRANES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals