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Title: Synthesis and biological activity of gem-dichlorocyclopropyl ethers

Abstract

In order to examine the antimicrobial activity of oxygenated cyclopropanes, the authors have synthesized the bis-gem-dichlorocyclopropyl ether of ethylene glycol, the meso- and dl- forms of bis-gem-dichlorocyclopropyl ether, and the gem-dichlorocyclopropyl alkyl ethers. The physiocochemical properties of compounds obtained are presented. The authors conclude that in the case of gem-dichlorocyclopropane compounds, decontamination of microorganisms occurs at the pre-metabolic stage, and results in the denaturation of the protein components of the cell wall and external membranes and of the specific peptides of the peptide-glycan layer.

Authors:
; ;
Publication Date:
Research Org.:
All-Union Research Institute for Organic Synthesis, Moscow (USSR)
OSTI Identifier:
6324220
Resource Type:
Journal Article
Journal Name:
Pharmaceut. Chem. J.; (United States)
Additional Journal Information:
Journal Volume: 19:11; Other Information: Translated from Khimiko-Farmatsevticheski Zhurnal; 19: No. 11, 1330-1335(Nov 1985)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANTIMICROBIAL AGENTS; BIOLOGICAL EFFECTS; NMR SPECTRA; SYNTHESIS; TOXICITY; ETHERS; BACTERIA; CHEMICAL SHIFT; CHLORINATED ALIPHATIC HYDROCARBONS; CYCLOALKANES; DOSE-RESPONSE RELATIONSHIPS; FUNGI; GLYCOLS; INFRARED SPECTRA; MULTIPLETS; PATHOGENS; ALCOHOLS; ALKANES; ANTI-INFECTIVE AGENTS; DRUGS; HALOGENATED ALIPHATIC HYDROCARBONS; HYDROCARBONS; HYDROXY COMPOUNDS; MICROORGANISMS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PLANTS; SPECTRA; 550700* - Microbiology; 560300 - Chemicals Metabolism & Toxicology; 550500 - Metabolism

Citation Formats

Shostakovskii, S M, Mochalov, V N, and Larionov, G M. Synthesis and biological activity of gem-dichlorocyclopropyl ethers. United States: N. p., 1986. Web.
Shostakovskii, S M, Mochalov, V N, & Larionov, G M. Synthesis and biological activity of gem-dichlorocyclopropyl ethers. United States.
Shostakovskii, S M, Mochalov, V N, and Larionov, G M. 1986. "Synthesis and biological activity of gem-dichlorocyclopropyl ethers". United States.
@article{osti_6324220,
title = {Synthesis and biological activity of gem-dichlorocyclopropyl ethers},
author = {Shostakovskii, S M and Mochalov, V N and Larionov, G M},
abstractNote = {In order to examine the antimicrobial activity of oxygenated cyclopropanes, the authors have synthesized the bis-gem-dichlorocyclopropyl ether of ethylene glycol, the meso- and dl- forms of bis-gem-dichlorocyclopropyl ether, and the gem-dichlorocyclopropyl alkyl ethers. The physiocochemical properties of compounds obtained are presented. The authors conclude that in the case of gem-dichlorocyclopropane compounds, decontamination of microorganisms occurs at the pre-metabolic stage, and results in the denaturation of the protein components of the cell wall and external membranes and of the specific peptides of the peptide-glycan layer.},
doi = {},
url = {https://www.osti.gov/biblio/6324220}, journal = {Pharmaceut. Chem. J.; (United States)},
number = ,
volume = 19:11,
place = {United States},
year = {Mon Sep 01 00:00:00 EDT 1986},
month = {Mon Sep 01 00:00:00 EDT 1986}
}