Influence of environmental lead on membrane ion transport in a French urban male population
- U169 INSERM Hopital Paul Brousse, Villejuif (France)
Red cell cation transports (Na(+)-K+ pump, Na(+)-K+ cotransport system, Na(+)-Li+ countertransport, and Na+ and K+ passive permeabilities) and blood and hair lead levels were measured in 129 healthy adult Caucasians not occupationally exposed to lead. In agreement with previously reported in vitro results showing a lead-induced Na(+)-K+ ATPase inhibition, Na(+)-K+ pump activity was inversely correlated with hair lead (r = -0.18, P less than 0.05); it was not significantly correlated with blood lead. Na(+)-K+ cotransport activity was inversely correlated with blood lead contents (r = -0.23, P less than 0.05) but not with hair lead. No significant correlation was found between the remaining cation transport pathways and lead levels. It is hypothesized that environmental, long-term exposure to lead may result in pump inhibition, while a recent exposition to lead may result in inhibition of the Na(+)-K+ cotransport system. Further research is required in order to determine if red cell Na(+)-K+ pump and Na(+)-K+ cotransport activities are sensitive indicators of chronic and recent exposures to lead, respectively.
- OSTI ID:
- 6318811
- Journal Information:
- Environmental Research; (USA), Vol. 53:2; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
Similar Records
Influence of membrane sodium transport upon the relation between blood lead and blood pressure in a general male population
Low level lead inhibits the human brain cation pump
Related Subjects
LEAD
TOXICITY
POTASSIUM COMPOUNDS
MEMBRANE TRANSPORT
SODIUM COMPOUNDS
ATP-ASE
CELL MEMBRANES
ENVIRONMENTAL EXPOSURE
ERYTHROCYTES
FRANCE
HAIR
MAN
METABOLISM
PERMEABILITY
URBAN AREAS
ACID ANHYDRASES
ALKALI METAL COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CONSTITUENTS
ELEMENTS
ENZYMES
EUROPE
HYDROLASES
MAMMALS
MATERIALS
MEMBRANES
METALS
ORGANS
PHOSPHOHYDROLASES
PRIMATES
SKIN
VERTEBRATES
WESTERN EUROPE
560300* - Chemicals Metabolism & Toxicology