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Title: Multivariate normal genetic models with a finite number of loci

A genetic model due to Russell Lande is described. The model assumes a finite number of loci at each of which there are an infinite number of alleles whose effects on the phenotype are normally distributed. Analytic and numerical results using this model depend on the allele effects remaining multivariate normally distributed. This is almost never exactly true, but may often be a good approximation. Numerical results for several kinds of natural selection are discussed. A model involving overdominance is presented which seems to exhibit the Franklin--Lewontin crystallization effect. A model is presented of the maintenance of genetic variation by a cline along which there is linear change in the optimum phenotype under optimizing selection. The equilibrium has been found analytically for the case of an infinite cline. Remarkably, there is no linkage disequilibrium maintained at equilibrium in this case.
Authors:
Publication Date:
OSTI Identifier:
6315326
Report Number(s):
RLO-2225/5-39
DOE Contract Number:
EY-76-S-06-2225-005
Resource Type:
Technical Report
Research Org:
Washington Univ., Seattle (USA). Dept. of Genetics
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GENETIC VARIABILITY; GENETICS; MATHEMATICAL MODELS; CHROMOSOMES; PHENOTYPE; BIOLOGICAL VARIABILITY; BIOLOGY 550400* -- Genetics