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Title: Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain

Abstract

The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.

Authors:
;
Publication Date:
Research Org.:
Research and Development Lab., Soedertaelje, Sweden
OSTI Identifier:
6304590
Resource Type:
Journal Article
Journal Name:
Life Sci.; (United States)
Additional Journal Information:
Journal Volume: 34:6
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTIDEPRESSANTS; RADIOASSAY; ANTIHISTAMINICS; BRAIN; CHEMICAL BONDS; GUINEA PIGS; HISTAMINE; LABELLED COMPOUNDS; RECEPTORS; SMALL INTESTINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; ANIMALS; AZOLES; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; INTESTINES; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PSYCHOTROPIC DRUGS; RODENTS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Hall, H, and Oegren, S O. Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain. United States: N. p., 1984. Web. doi:10.1016/0024-3205(84)90494-6.
Hall, H, & Oegren, S O. Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain. United States. https://doi.org/10.1016/0024-3205(84)90494-6
Hall, H, and Oegren, S O. 1984. "Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain". United States. https://doi.org/10.1016/0024-3205(84)90494-6.
@article{osti_6304590,
title = {Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain},
author = {Hall, H and Oegren, S O},
abstractNote = {The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.},
doi = {10.1016/0024-3205(84)90494-6},
url = {https://www.osti.gov/biblio/6304590}, journal = {Life Sci.; (United States)},
number = ,
volume = 34:6,
place = {United States},
year = {Mon Feb 06 00:00:00 EST 1984},
month = {Mon Feb 06 00:00:00 EST 1984}
}