Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain
Abstract
The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.
- Authors:
- Publication Date:
- Research Org.:
- Research and Development Lab., Soedertaelje, Sweden
- OSTI Identifier:
- 6304590
- Resource Type:
- Journal Article
- Journal Name:
- Life Sci.; (United States)
- Additional Journal Information:
- Journal Volume: 34:6
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; ANTIDEPRESSANTS; RADIOASSAY; ANTIHISTAMINICS; BRAIN; CHEMICAL BONDS; GUINEA PIGS; HISTAMINE; LABELLED COMPOUNDS; RECEPTORS; SMALL INTESTINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; ANIMALS; AZOLES; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; INTESTINES; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PSYCHOTROPIC DRUGS; RODENTS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
Citation Formats
Hall, H, and Oegren, S O. Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain. United States: N. p., 1984.
Web. doi:10.1016/0024-3205(84)90494-6.
Hall, H, & Oegren, S O. Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain. United States. https://doi.org/10.1016/0024-3205(84)90494-6
Hall, H, and Oegren, S O. 1984.
"Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain". United States. https://doi.org/10.1016/0024-3205(84)90494-6.
@article{osti_6304590,
title = {Effects of antidepressant drugs on histamine-H/sub 1/ receptors in the brain},
author = {Hall, H and Oegren, S O},
abstractNote = {The histamine-H/sub 1/ receptor blocking properties of a number of structurally different antidepressant drugs have been evaluated using a /sup 3/H-mepyramine binding assay and a guinea-pig ileum preparation. The tricyclic antidepressants all inhibited the histamine-H/sub 1/ receptor. Some newer antidepressant drugs, such as zimeldine and nomifensine were devoid of activity while others, such as iprindole and mianserin were very potent. It is concluded that antagonistic effects on the histamine-H/sub 1/ receptor is not associated with the therapeutic efficacy in depression, but may contribute to the sedative effects of the antidepressant drugs.},
doi = {10.1016/0024-3205(84)90494-6},
url = {https://www.osti.gov/biblio/6304590},
journal = {Life Sci.; (United States)},
number = ,
volume = 34:6,
place = {United States},
year = {Mon Feb 06 00:00:00 EST 1984},
month = {Mon Feb 06 00:00:00 EST 1984}
}
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