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Title: Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion

Abstract

Both I-123 IMP scintigraphy and MRI have been suggested as sensitive detectors of changes shortly after acute cerebral infarction. We compared the uptake of N-isopropyl I-123 p-iodoamphetamine (IMP) and MR spectroscopy of the brain after internal carotid artery ligation. Thirteen gerbils were lightly anesthetized with ether. After neck dissection, an internal carotid artery was occluded. After 2.8 hours, 100 muCi I-123 IMP was injected intravenously into the 13 experimental animals plus three controls. Seven gerbils remained asymptomatic while six developed hemiparesis. At 3 hours after ligation, the animals were killed. The brains were bisected and T1 and T2 relaxation times were determined for the right and left hemispheres by MR spectroscopy immediately after dissection. I-123 IMP uptake was then determined in the samples. Interhemispheric differences in uptake for I-123 IMP were 0.1 +/- 1.7% (SEM) in the control, 33.5 +/- 10% in the asymptomatic and 54.6 +/- 9.7% in the symptomatic animals. Significant differences were seen with I-123 IMP in 6/7 asymptomatic and 6/6 symptomatic animals. In conclusion, I-123 is more sensitive than T1 or T2 relaxation times for the detection of cerebral perfusion abnormalities. Prolongation in T1 and T2 relaxation times correlates closely with increased brain tissue water contentmore » and the development of symptoms, indicators of structural brain damage and probable infarction.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Harvard Medical School, Boston, MA
OSTI Identifier:
6300357
Resource Type:
Journal Article
Journal Name:
Invest. Radiol.; (United States)
Additional Journal Information:
Journal Volume: 4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; SCINTISCANNING; IODINE 123; UPTAKE; VASCULAR DISEASES; DIAGNOSIS; AMPHETAMINES; COMPARATIVE EVALUATIONS; GERBILS; NUCLEAR MAGNETIC RESONANCE; PERFUSED ORGANS; ANALEPTICS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAGNETIC RESONANCE; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESONANCE; RODENTS; SYMPATHOMIMETICS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Holman, B L, Jolesz, F A, Polak, J F, Kronauge, J F, and Adams, D F. Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion. United States: N. p., 1985. Web. doi:10.1097/00004424-198507000-00006.
Holman, B L, Jolesz, F A, Polak, J F, Kronauge, J F, & Adams, D F. Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion. United States. https://doi.org/10.1097/00004424-198507000-00006
Holman, B L, Jolesz, F A, Polak, J F, Kronauge, J F, and Adams, D F. 1985. "Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion". United States. https://doi.org/10.1097/00004424-198507000-00006.
@article{osti_6300357,
title = {Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion},
author = {Holman, B L and Jolesz, F A and Polak, J F and Kronauge, J F and Adams, D F},
abstractNote = {Both I-123 IMP scintigraphy and MRI have been suggested as sensitive detectors of changes shortly after acute cerebral infarction. We compared the uptake of N-isopropyl I-123 p-iodoamphetamine (IMP) and MR spectroscopy of the brain after internal carotid artery ligation. Thirteen gerbils were lightly anesthetized with ether. After neck dissection, an internal carotid artery was occluded. After 2.8 hours, 100 muCi I-123 IMP was injected intravenously into the 13 experimental animals plus three controls. Seven gerbils remained asymptomatic while six developed hemiparesis. At 3 hours after ligation, the animals were killed. The brains were bisected and T1 and T2 relaxation times were determined for the right and left hemispheres by MR spectroscopy immediately after dissection. I-123 IMP uptake was then determined in the samples. Interhemispheric differences in uptake for I-123 IMP were 0.1 +/- 1.7% (SEM) in the control, 33.5 +/- 10% in the asymptomatic and 54.6 +/- 9.7% in the symptomatic animals. Significant differences were seen with I-123 IMP in 6/7 asymptomatic and 6/6 symptomatic animals. In conclusion, I-123 is more sensitive than T1 or T2 relaxation times for the detection of cerebral perfusion abnormalities. Prolongation in T1 and T2 relaxation times correlates closely with increased brain tissue water content and the development of symptoms, indicators of structural brain damage and probable infarction.},
doi = {10.1097/00004424-198507000-00006},
url = {https://www.osti.gov/biblio/6300357}, journal = {Invest. Radiol.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {Mon Jul 01 00:00:00 EDT 1985},
month = {Mon Jul 01 00:00:00 EDT 1985}
}