Multiple-dose study of oral pyridostigmine in swine. Interim report, January 1986-January 1987

Technical Report · Sun Mar 01 00:00:00 EST 1987

OSTI ID:6295782

Wade, C E; Waring, P P; Trail, D S; Williams, B F; Bonner, G D

The hemodynamic, metabolic, and hormonal responses to pyridostigmine treatment were evaluated in immature swine(20.7 + or - 0.5 kg). Pyridostigmine bromide was administered orally three times per day at 60 mg per dose. Animals receiving treatment (n=12) were compared to a group with no treatment (n=14). After three days of treatment, plasma and erythrocyte cholinesterase activities were reduced by 31% and 47%, respectively. Blood gases, heart rate, and blood pressure were not different. Pyridostigmine tended to increase blood glucose levels and elevated hematocrits 26 to 29%. Treatment with 60 mg of pyridostigmine three times daily for three days reduced acetylcholinesterase activity as desired in man for prophylactic treatment against possible exposure to nerve agents. In swine this degree of inhibition of acetylcholinesterase activity was associated with an index of stress, a slight increase in hematocrit. Swine appear to offer an effective animal model in which to evaluate pyridostigmine treatment.

• Research Organization: Letterman Army Inst. of Research, San Francisco, CA (USA)
• OSTI ID: 6295782
• Report Number(s): AD-A-180422/8/XAB; LAIR-87-67
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CHEMICAL WARFARE AGENTS
EVALUATION
PHARMACOLOGY
BLOOD CHEMISTRY
BLOOD PRESSURE
CHEMICAL WARFARE
CHOLINESTERASE
ERYTHROCYTES
GLUCOSE
INDEXES
INHIBITION
PREVENTIVE MEDICINE
STRESSES
SWINE
ALDEHYDES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLESTERASES
DOCUMENT TYPES
DOMESTIC ANIMALS
ENZYMES
ESTERASES
HEXOSES
HYDROLASES
MAMMALS
MATERIALS
MEDICINE
MONOSACCHARIDES
ORGANIC COMPOUNDS
SACCHARIDES
VERTEBRATES
WARFARE
WEAPONS
400201* - Chemical & Physicochemical Properties