Epithelial cell proliferation in human fundic and antral mucosae. Influence of superselective vagotomy and relationship with gastritis
Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se.
- Research Organization:
- INSERM U.10, Paris, France
- OSTI ID:
- 6294173
- Journal Information:
- Dig. Dis. Sci.; (United States), Vol. 11
- Country of Publication:
- United States
- Language:
- English
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MUCOUS MEMBRANES
AUTORADIOGRAPHY
CELL PROLIFERATION
VAGUS
SURGERY
DIGESTIVE SYSTEM DISEASES
EPITHELIUM
INFLAMMATION
PATIENTS
STOMACH
THYMIDINE
TRITIUM COMPOUNDS
ULCERS
ANIMAL TISSUES
AUTONOMIC NERVOUS SYSTEM
AZINES
BODY
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MEDICINE
MEMBRANES
NERVES
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PYRIMIDINES
RIBOSIDES
SYMPTOMS
TISSUES
551001* - Physiological Systems- Tracer Techniques