Antifertility and mutagenic effects in mice from parenteral administration of di-2-ethylhexyl phthalate (DEHP)
The subcutaneous administration of 1-10 mg of undiluted di-(2-ethylhexyl)phthalate (DEHP) to adult male ICR mice on d 1, 5, and 10 was followed by mating, one to one, with untreated adult virgin females. A single mating at d 21 resulted in a reduction in the incidence of pregnancies in the DEHP-treated groups. On the other hand, repeated matings with fresh females starting on d 2, 6, 11, 16, and 21, and at weekly intervals through 8 wk, revealed no perceptible effect of DEHP on the incidence of pregnancy. Examination of surgically exposed uteri and ovaries of pregnant females on d 13 of gestation revealed an increase in the incidence of preimplantation losses and early fetal deaths in the DEHP-treated groups; consequently, there were fewer viable fetuses per pregnancy. Mutagenic indices for DEHP, calculated as percent ratios of (1) preimplantation losses/implantations per pregnancy and (2) early fetal deaths/implantations per pregnancy, suggested a dominant lethal mutation effect in the treated mice. These effects tend to be more pronounced on the postmiotic stage of germ-cell development.
- Research Organization:
- Univ. of Tennessee Center for the Health Sciences, Memphis
- OSTI ID:
- 6290103
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 16:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Prenatal toxicology of shale oil retort water in mice
DEHP exposure in utero disturbs sex determination and is potentially linked with precocious puberty in female mice
Related Subjects
MICE
FERTILITY
LETHAL MUTATIONS
PHTHALIC ACID ESTERS
MUTAGENESIS
TOXICITY
FETUSES
REPRODUCTIVE DISORDERS
SUBCUTANEOUS INJECTION
VIABILITY
ANIMALS
ESTERS
INJECTION
INTAKE
MAMMALS
MUTATIONS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)