Temporal behavior of peripheral organ distribution volume in mammillary systems. II. Application to background correction in separate glomerular filtration rate estimation in man

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6282809

Decostre, P L; Salmon, Y ^[1]

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1. Hopital Civil, Jumet (Belgium)

An original approach to background subtraction is presented for 99mTc-DTPA separate glomerular filtration rate (SGFR) estimation in man. The method is based on the properties of the peripheral organ distribution volume (PODV) in mammillary systems. These PODV properties allow easy separation of the components of the renogram, i.e., interstitial fluid, plasma and renal activities. The proposed algorithm takes advantage of the linear time dependence of the kidney distribution volume, during the renal uptake phase, to correct for the plasma residual activity, which always remains after classical background correction. Theoretically, the ratio between kidney uptake and SGFR should be identical for both left and right kidneys, even for very asymmetrical kidney functions. This is best verified when the proposed plasma residual activity correction is applied.

• OSTI ID: 6282809
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:10; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
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KIDNEYS
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
ALGORITHMS
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IMAGE PROCESSING
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TIME DEPENDENCE
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CHELATING AGENTS
DISTRIBUTION
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATHEMATICAL LOGIC
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
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& Toxicology- Man