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Title: Environmental neurotoxicity of chemicals and radiation

Epidemiologic and societal concerns continue to stimulate studies in the field of environmental neurotoxicology. Although the role of heavy metals, aluminum, and iron are unclear in the etiology of human neurodegenerative disorders, these toxins have provided fertile ground for in vivo and in vitro experimental studies to elucidate their role in neurotoxic injury. Experimental models of clinical syndromes are discussed with special relevance to developmental neurotoxicology. Cycloleucine, tellurium, and 1,3-dinitrobenzene provide models of subacute combined degeneration, primary peripheral nerve demyelination, and thiamine deficiency-like lesions, respectively. Increasing attention is being given to irradiation neurotoxicity, especially in the developing or young central nervous system. A fuller understanding of the pathogenesis of low-dose irradiation injury allows for a clearer understanding of its neurobiology and also provides a more rational approach to understanding an interventional therapy associated with brain irradiation for childhood neoplasia. 43 refs.
Authors:
 [1]
  1. (Univ. of California, Los Angeles (United States))
Publication Date:
OSTI Identifier:
6282349
Resource Type:
Journal Article
Resource Relation:
Journal Name: Current Opinion in Neurology and Neurosurgery; (United States); Journal Volume: 6:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CENTRAL NERVOUS SYSTEM; INJURIES; LOW DOSE IRRADIATION; PATHOGENESIS; TOXICITY; METALS; NERVOUS SYSTEM DISEASES; ETIOLOGY; RADIOTHERAPY; ALUMINIUM; BRAIN; IN VITRO; IN VIVO; IRON; RADIATION INJURIES; TELLURIUM; THIAMINE; TOXIC MATERIALS; TOXINS; AMINES; ANTIGENS; AZINES; AZOLES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELEMENTS; HAZARDOUS MATERIALS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IRRADIATION; MATERIALS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PYRIMIDINES; RADIATION EFFECTS; RADIOLOGY; SEMIMETALS; THERAPY; THIAZOLES; TRANSITION ELEMENTS; VITAMIN B GROUP; VITAMINS 560300* -- Chemicals Metabolism & Toxicology; 560151 -- Radiation Effects on Animals-- Man