Effect of disodium cromoglycate (DSCG) and antihistamines on post-irradiation cerebral blood flow and plasma levels of histamine and neurotensin
In an attempt to elucidate mechanisms underlying the irradiation-induced decrease in regional cerebral blood flow (rCBF) in primates, hippocampal and visual cortical blood flows of rhesus monkeys were measured by hydrogen clearance, before and after exposure to 100-Gy, whole-body, gamma irradiation. Systemic blood pressures were monitored simultaneously. Systemic arterial plasma histamine and neurotensin levels were determined preirradiation and postirradiation. Compared to control animals, the irradiated monkeys exhibited an abrupt decline in systemic blood pressure to 23% of the preirradiation level within 10-min postirradiation, falling to 12% by 60 min. A decrease in hippocampal blood flow to 32% of the preirradiation level was noted at 10-min postirradiation, followed by a slight recovery to 43% at 30 min and a decline to 23% by 60 min. The cortical blood flow for the same animals showed a steady decrease to 29% of the preirradiation levels by 60-min postirradiation. Animals given the mast-cell stabilizer disodium cromoglycate and the antihistamines mepyramine and cimetidine before irradiation did not exhibit an abrupt decline in blood pressure but displayed a gradual decrease to a level 33% below preirradiation levels by 60 min postirradiation. Also, the treated, irradiated monkeys displayed rCBF values that were not significantly different from the nonirradiated controls. The plasma neurotensin levels in the irradiated animals, treated and untreated, indicated a nonsignificant postirradiation increase above control levels.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6275910
- Report Number(s):
- AD-A-203429/6/XAB; AFRRI-SR-88-3
- Resource Relation:
- Other Information: Pub. in Fundamental and Applied Toxicology, Vol. 10, 233-242(1988)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIHISTAMINICS
BLOOD FLOW
BIOLOGICAL RADIATION EFFECTS
CEREBRUM
ARTERIES
BLOOD CHEMISTRY
BLOOD PLASMA
BLOOD PRESSURE
CONTROL
EFFICIENCY
HIPPOCAMPUS
HISTAMINE
LABORATORY ANIMALS
PROTEINS
SODIUM COMPOUNDS
WHOLE-BODY IRRADIATION
ALKALI METAL COMPOUNDS
AMINES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD VESSELS
BODY
BODY FLUIDS
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DRUGS
EXTERNAL IRRADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MATERIALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
560152* - Radiation Effects on Animals- Animals