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Title: Early inhibition of natural and interferon-activated killers in endometrial cancer patients treated with local radiotherapy

Abstract

The present study was aimed at comparing the effect of clinical staging and radiotherapy on natural killer (NK) and interferon-activated killer (IAK) cell activity in a group of endometrial cancer patients receiving a total dose of 5,000 to 8,000 rads. We report that when compared to age-matched women, a significantly higher number and percentage of patients show low NK and IAK cell activity. At diagnosis, diminished NK activity was seen in about 20% of the patients, while IAK activity was low in 49% of these patients. There was no correlation between these deficiencies and the grade or stage of the disease. In contrast, radiotherapy induced deleterious effects on both populations of NK and IAK cells. These deleterious effects were more pronounced in patients showing a low level of spontaneous NK activity. In an attempt to understand better the mechanism by which the presence of cancer itself and/or radiotherapy affects these activities, we studied in greater detail changes in peripheral blood T-cell numbers and subsets. Before radiotherapy, all lymphocyte counts were within the normal range. In contrast, after radiotherapy the absolute numbers of all T-cell subsets were significantly decreased in the majority of the patients tested, OKT4+ cells being the mostmore » radiosensitive and Leu 7+ cells the most radioresistant.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of Quebec, Ville de Laval
OSTI Identifier:
6273981
Resource Type:
Journal Article
Journal Name:
Cancer Detect. Prev.; (United States)
Additional Journal Information:
Journal Volume: 1-2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; LYMPHOCYTES; RADIOSENSITIVITY; NEOPLASMS; RADIOTHERAPY; SIDE EFFECTS; UTERUS; INHIBITION; INTERFERON; PATIENTS; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; FEMALE GENITALS; GROWTH FACTORS; LEUKOCYTES; LYMPHOKINES; MATERIALS; MEDICINE; MITOGENS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOLOGY; SOMATIC CELLS; THERAPY; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Mandeville, R, Sidrac-Ghali, S, Ajdukovic, I, Vidal, D, and Ayoub, J. Early inhibition of natural and interferon-activated killers in endometrial cancer patients treated with local radiotherapy. United States: N. p., 1987. Web.
Mandeville, R, Sidrac-Ghali, S, Ajdukovic, I, Vidal, D, & Ayoub, J. Early inhibition of natural and interferon-activated killers in endometrial cancer patients treated with local radiotherapy. United States.
Mandeville, R, Sidrac-Ghali, S, Ajdukovic, I, Vidal, D, and Ayoub, J. 1987. "Early inhibition of natural and interferon-activated killers in endometrial cancer patients treated with local radiotherapy". United States.
@article{osti_6273981,
title = {Early inhibition of natural and interferon-activated killers in endometrial cancer patients treated with local radiotherapy},
author = {Mandeville, R and Sidrac-Ghali, S and Ajdukovic, I and Vidal, D and Ayoub, J},
abstractNote = {The present study was aimed at comparing the effect of clinical staging and radiotherapy on natural killer (NK) and interferon-activated killer (IAK) cell activity in a group of endometrial cancer patients receiving a total dose of 5,000 to 8,000 rads. We report that when compared to age-matched women, a significantly higher number and percentage of patients show low NK and IAK cell activity. At diagnosis, diminished NK activity was seen in about 20% of the patients, while IAK activity was low in 49% of these patients. There was no correlation between these deficiencies and the grade or stage of the disease. In contrast, radiotherapy induced deleterious effects on both populations of NK and IAK cells. These deleterious effects were more pronounced in patients showing a low level of spontaneous NK activity. In an attempt to understand better the mechanism by which the presence of cancer itself and/or radiotherapy affects these activities, we studied in greater detail changes in peripheral blood T-cell numbers and subsets. Before radiotherapy, all lymphocyte counts were within the normal range. In contrast, after radiotherapy the absolute numbers of all T-cell subsets were significantly decreased in the majority of the patients tested, OKT4+ cells being the most radiosensitive and Leu 7+ cells the most radioresistant.},
doi = {},
url = {https://www.osti.gov/biblio/6273981}, journal = {Cancer Detect. Prev.; (United States)},
number = ,
volume = 1-2,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1987},
month = {Thu Jan 01 00:00:00 EST 1987}
}