In vivo effect of fly ash on surface receptors of mice peritoneal macrophages

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Environ. Sci. Health, Part A; (United States)

DOI:https://doi.org/10.1080/10934528709375342· OSTI ID:6271540

Dogra, S; Khanna, A K; Kaw, J L

Functional activity of macrophages was studied in mice up to 15 days after intraperitoneal injection of 2.5 and 5.0 mg of fly ash using in vitro parameters. Fly ash did not cause any variation in the type of cellular response. The total cell number decreased significantly by 4 days after fly ash treatment but recovered subsequently. The decrease was dose dependent. Fly ash also caused a 50% depression in the FC receptor mediated phagocytosis of IgG coated sheep erythrocytes (SRBC) by macrophages at 2 days of dust treatment. However, the recovery began earlier with 2.5 mg fly ash than with 5.0 mg fly ash. These changes were not associated with any marked changes in esterase activity of macrophages following phagocytosis of fly ash.

• Research Organization: Industrial Toxicology Research Centre, Lucknow, India
• OSTI ID: 6271540
• Journal Information: J. Environ. Sci. Health, Part A; (United States), Vol. A22:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FLY ASH
BIOLOGICAL EFFECTS
MACROPHAGES
ENZYME ACTIVITY
RECEPTORS
MICE
ESTERASES
AEROSOL WASTES
ANIMAL CELLS
ANIMALS
ASHES
CONNECTIVE TISSUE CELLS
ENZYMES
HYDROLASES
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
PHAGOCYTES
PROTEINS
RESIDUES
RODENTS
SOMATIC CELLS
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology