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Title: Pilot studies of superfractionated radiotherapy and combination chemotherapy in limited oat cell carcinoma of the bronchus

There are sound radiobiologic and suggestive clinical rationale for superfractionating the radiotherapeutic regimens employed for the therapy of rapidly growing malignancies. Oat cell carcinoma of the bronchus is such a tumor. The authors report their experience combining aggressive systemic combination chemotherapy with supperfractionated radiotherapy for the treatment of limited oat cell carcinoma of the bronchus. Overall, patient tolerance was satisfactory and a complete remission rate of 74% was achieved. It remains to be proven, in a prospective randomized fashion, whether this approach is superior to current conventional management.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6268459
Resource Type:
Journal Article
Resource Relation:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States); Journal Volume: 10:10
Research Org:
Univ. of Manitoba, Winnipeg
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BRONCHI; BIOLOGICAL RADIATION EFFECTS; FIBROSIS; RADIOINDUCTION; IMMUNOSUPPRESSION; RADIOTHERAPY; SIDE EFFECTS; CARCINOMAS; CHEMOTHERAPY; COBALT 60; ENDOXAN; FRACTIONATED IRRADIATION; GAMMA RADIATION; NITROSOUREAS; ONCOVIN; PATIENTS; X RADIATION; ALKALOIDS; ALKYLATING AGENTS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; COBALT ISOTOPES; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; IMMUNOSUPPRESSIVE DRUGS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NEOPLASMS; NITROSO COMPOUNDS; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; YEARS LIVING RADIOISOTOPES 560151* -- Radiation Effects on Animals-- Man; 550603 -- Medicine-- External Radiation in Therapy-- (1980-)