Toxic Hazards Research Unit annual report, 1990. Annual report No. 27 (Final), 1 Oct 89-15 Nov 90

Technical Report · Sat Dec 01 00:00:00 EST 1990

OSTI ID:6264184

Wall, H G; Vinegar, A; Kinkead, E R

This report presents a review of the activities of the Toxic Hazards Research Unit for the period of 1 October 1989 through 15 November 1990. Research activities focused on toxicity evaluations of aerospace and naval chemicals to include aircraft fuels and rocket fuels, hydraulic fluids, ground water contaminants, and chemical defense simulants. There was increased utilization of multidisciplinary efforts for quantitative toxicology studies and the development and validation of physiologically based pharmacokinetic models for predicting toxicity responses. The General Toxicology Laboratory conducted acute studies, toxicokinetic studies, repeated-dose studies, and subchronic inhalation studies to include a 90-day continuous inhalation study using the Thomas Domes. The development and characterization of a unique high pressure aerosol generator was a significant adjunct benefitting the study conducted in the Thomas Domes.

• Research Organization: NSI Technology Services Corp., Dayton, OH (United States). Environmental Sciences
• OSTI ID: 6264184
• Report Number(s): AD-A-240472/1/XAB; CNN: F33615-85-C-0532
• Country of Publication: United States
• Language: English

Related Subjects

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
AEROSOL GENERATORS
DESIGN
AVIATION FUELS
TOXICITY
CHEMICAL WARFARE AGENTS
HYDRAULIC FLUIDS
CHEMICAL ANALYSIS
DOSE-RESPONSE RELATIONSHIPS
HAZARDOUS MATERIALS
INHALATION
VALIDATION
FLUIDS
FUELS
INTAKE
MATERIALS
TESTING
WEAPONS
WORKING FLUIDS
450600* - Military Technology
Weaponry
& National Defense- Chemical & Biological- (1990)
560300 - Chemicals Metabolism & Toxicology
540120 - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)