The influence of cyclosporin A on experimental autoimmune thyroid disease in the rat
Female PVG/c rats, thymectomised on weaning and given 4 courses of whole body irradiation to a total dose of 1000 rads, developed experimental autoimmune thyroid disease (EAITD) as assessed by histological evidence of thyroiditis and circulating levels of antithyroglobulin antibodies. Hypothyroidism resulted. Induction of the disease was associated with a highly significant fall in T lymphocyte numbers. Eight weeks after their last dose of irradiation the animals commenced treatment with cyclosporin A (10 mg/kg rat/day, intragastrically) and were treated for varying time intervals thereafter. The reversal of the T lymphocyte helper: suppressor ratio on cyclosporin A therapy was associated with a significant improvement in the disease process. The alterations in the T cell subsets and in the disease lasted only as long as the drug was administered and thereafter reverted towards that seen in the control groups of animals receiving no treatment.
- Research Organization:
- Welsh National School of Medicine, Cardiff, Wales
- OSTI ID:
- 6253340
- Journal Information:
- Life Sci.; (United States), Vol. 32:1,2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HYPOTHYROIDISM
RADIOINDUCTION
THERAPY
WHOLE-BODY IRRADIATION
BIOLOGICAL RADIATION EFFECTS
ANTIBIOTICS
IMMUNE REACTIONS
LYMPHOCYTES
RATS
THYMECTOMY
THYROIDITIS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ENDOCRINE DISEASES
EXTERNAL IRRADIATION
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
MEDICINE
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
SURGERY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)